Pharmacologic androgen deprivation and cardiovascular disease risk factors: a systematic review

European Journal of Clinical Investigation
Matthew L RomoC Mary Schooling

Abstract

Pharmacologic androgen deprivation therapy (ADT) is widely used to treat prostate cancer. Observational studies suggest ADT is associated with cardiovascular disease and its risk factors; however, such studies may be subject to bias. Our objective was to evaluate the effect of ADT on cardiovascular disease risk factors using data from randomized controlled trials (RCTs). We conducted a systematic review using MEDLINE and MEDLINE In-Process (1950-June 2013), EMBASE (1974-June 2013) and Web of Science (1900-June 2013) for all RCTs in men with prostate cancer that compared pharmacologic ADT (i.e. use of gonadotropin-releasing hormone agonist or antagonist) with a group that did not receive ADT and reported data on cardiovascular disease risk factors including blood pressure, cholesterol, triglycerides, fibrinogen, biomarkers of insulin sensitivity, adiposity and C-reactive protein. We also searched for ongoing or unpublished trials. This study was registered at the PROSPERO International Prospective Register of Systematic Reviews (CRD42013005035). Of the 3272 unique publications identified in our systematic review, we did not identify a single RCT that reported data on any cardiovascular disease risk factor. We were unable to loca...Continue Reading

References

Dec 15, 1992·Annals of Internal Medicine·D GradyS R Cummings
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·J LaverdièreF Labrie
May 23, 1998·The Journal of Urology·G AusK Pedersen
May 29, 1998·Circulation·P W WilsonW B Kannel
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Jun 6, 2003·European Heart Journal·R M ConroyUNKNOWN SCORE project group
Sep 18, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David S LambGillian Duchesne
Aug 18, 2004·The Journal of Urology·Fritz H SchröderUNKNOWN Members of the European Organisation for the Research and Treatment of Cancer Genito-urinary Group
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
Jul 28, 2007·Cancer·Christopher S SaigalUNKNOWN Urologic Diseases in America Project
Oct 11, 2007·Journal of the National Cancer Institute·Henry K TsaiPeter R Carroll
Jan 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mack RoachMiljenko V Pilepich
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jason A EfstathiouMatthew R Smith
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Dec 10, 2009·Journal of the National Cancer Institute·Nancy L KeatingMatthew R Smith
Jan 9, 2010·European Journal of Clinical Investigation·I SimeraD G Altman
Feb 4, 2010·Circulation·Glenn N LevineUNKNOWN American Heart Association Council on Clinical Cardiology and Council on Epidemiology and Prevention, the American Cancer So
Feb 4, 2010·CA: a Cancer Journal for Clinicians·Glenn N LevineUNKNOWN American Heart Association Council on Clinical Cardiology and Council on Epidemiology and Prevention, the American Cancer So
Jun 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Shalender BhasinUNKNOWN Task Force, Endocrine Society
Jun 23, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mieke Van HemelrijckJan Adolfsson
Jul 15, 2011·The New England Journal of Medicine·Christopher U JonesWilliam U Shipley
Nov 18, 2011·Clinical Pharmacology and Therapeutics·S Hennessy
Dec 8, 2011·JAMA : the Journal of the American Medical Association·Paul L NguyenToni K Choueiri
Dec 23, 2011·European Journal of Endocrinology·L FrederiksenM Andersen

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Citations

May 11, 2016·The Journal of Urology·Laurence Klotz, Christopher P Evans
Mar 4, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Man Ki KwokC Mary Schooling
Feb 26, 2016·Journal of the American Heart Association·Christian Bo PoulsenJacob Fog Bentzon
Jan 14, 2016·Current Opinion in Supportive and Palliative Care·Richard J Wassersug

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