Jan 1, 1992

Pharmacologic effect of thiphenamil HCl on lower urinary tract function of healthy asymptomatic volunteers

Urologia Internationalis
C E Constantinou


The effect of thiphenamil HCl on the urodynamic parameters of bladder filling, voiding and isometric contraction was examined in controls. Data were obtained from 25 control female subjects with a mean age of 27.6 +/- 6.6 years. Three urodynamic studies were done on each subject on 3 different days. These studies were: (1) control study, (2) drug study with a single oral dose of 400 mg thiphenamil HCl and (3) another with 800 mg. Each urodynamic study involved filling and voiding cystometrograms to characterize stability, sensations of fullness and urgency, bladder capacity, urethral opening pressure, maximum flow rate, maximum detrusor pressure and residual urine. In addition, isometric detrusor pressure measurements were made at bladder volume increments of 100 ml. Each urodynamic study was done in the sitting position using medium fill water cystometry at 20 ml/min. Isometric pressures were made by catheterizing the subject with an 18-french three-way Foley catheter with a 30-ml balloon. One lumen was used to fill the bladder and the second to measure pressure. The results show that bladder capacity and the volume at which sensations of fullness and urgency are expressed are not significantly changed under the influence of t...Continue Reading

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Mentioned in this Paper

Thiphenamil hydrochloride
Entire Lumen of Body System
Neoplasm of Uncertain or Unknown Behavior of Bladder
Flow of Urine
Urinary Bladder Diseases
Sulfur Compounds
Carcinoma in Situ of Bladder

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