Pharmacologic intervention for retained placenta: a systematic review and meta-analysis

Obstetrics and Gynecology
James M N DuffyKhalid S Khan

Abstract

To assess the effectiveness and safety of pharmacologic interventions for the treatment of retained placenta (when the placenta remains undelivered after 30 minutes of active management of the third stage of labor). We searched: 1) Cochrane Central Register of Controlled Trials (CENTRAL), 2) Cochrane Pregnancy and Childbirth Group's Trials Register, 3) EMBASE, and 4) MEDLINE from inception to June 2014. Randomized controlled trials comparing a pharmacologic intervention(s) with a placebo for the treatment of retained placenta were included. Sixteen randomized controlled trials, including 1,683 participants, were included. Study characteristics and quality were recorded. The meta-analysis was based on random-effects methods for pooled data. There were no statistically significant differences in the requirement to perform manual removal of a placenta in patients treated with oxytocin (55% compared with 60%; relative risk [RR] 0.86, 95% confidence interval [CI] 0.73-1.02; 10 randomized controlled trials [RCTs]), prostaglandins (44% compared with 55%; RR 0.82, 95% CI 0.58-1.15; four RCTs), nitroglycerin (85% compared with 80%; RR 1.06, 95% CI 0.80-1.41; one RCT), or oxytocin and nitroglycerin (52% compared with 79%; RR 0.23, 95% CI...Continue Reading

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Citations

Oct 21, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohammad Ahmed MaherNabih Ibrahim Elkhouly
Jun 26, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Carlos F Grillo-ArdilaJuan C Amaya-Restrepo
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Mar 15, 2016·Current Opinion in Anaesthesiology·Hiroyuki Sumikura, Eiichi Inada
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Sep 6, 2021·The Journal of Obstetrics and Gynaecology Research·Kei FujitaTomomi Kotani
Jun 28, 2020·American Journal of Obstetrics and Gynecology·Haylea S PatrickMeike Schuster

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