Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries

Behavioural Pharmacology
Sachi Tanimoto-MoriYasuhiro Kita

Abstract

Cold allodynia is a frequent clinical symptom of patients with neuropathic pain. Despite numerous studies of cold allodynia, using animal models of neuropathic pain, little is known about its underlying mechanisms. This study was performed to establish a method for the pharmacologic evaluation of cold allodynia using several analgesics in a chronic constriction injury (CCI) rat model of neuropathic pain. Compared with the results obtained before the CCI operation, the CCI rats placed on a cork plate at 20 degrees C exhibited a slight change in the paw withdrawal latency because of the mechanical stimulus mediated by the injured paw touching the plate. By contrast, there was a significant reduction in the paw withdrawal latency on a cold metal plate compared with that on the cork plate after the CCI surgery, with the maximum decrease occurring on postoperative day 7. This reduction is thought to specifically reflect cold-induced pain behavior. In addition, both naïve and CCI rats showed behavioral changes at 5 and 0 degrees C, but not at 10 degrees C or higher. Interestingly, a subcutaneous morphine dose of 6 mg/kg completely inhibited cold allodynia induced at 10 degrees C on postoperative day 7. Under this condition, both the ...Continue Reading

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Citations

Dec 24, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Drake MorganChristy S Carter
Oct 17, 2013·Neuroscience Letters·Silke J Hirsch, Anthony H Dickenson
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Aug 25, 2018·Journal of the Chinese Medical Association : JCMA·Hou-Chuan LaiZhi-Fu Wu
Apr 21, 2017·Turkish Journal of Medical Sciences·Didem AkçaliHayrunnisa Bolay

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