Pharmacologic management of neovascular age-related macular degeneration: systematic review of economic evidence and primary economic evaluation

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
William HodgeAndra Morrison

Abstract

To examine the economic implications for the Canadian health system of pharmacologic treatment of neovascular age-related macular degeneration (AMD). Systematic review of economic literature and a primary economic evaluation. Economic literature search identified 392 potentially relevant articles, 12 of which were included for final review. Studies were included if they met the following criteria: (i) provision of a summary measure of the trade-off between costs and consequences; (ii) participants of 40 years and older with neovascular AMD; (iii) interventions and comparators: comparison of photodynamic therapy using verteporfin (V-PDT), pegaptanib, bevacizumab, ranibizumab, anecortave acetate, intravitreal triamcinolone, placebo, or clinically relevant combinations; and (iv) outcome reported as an incremental measure of the implication of moving from the comparator to the intervention. The following databases were searched through the OVID interface: MEDLINE, EMBASE, BIOSIS Previews, CINAHL, PubMed, Health Economic Evaluations Database (HEED), and the Cochrane Library. For the economic evaluation, we took a decision analytic approach and modeled a cost-utility analysis, conducting it as a microsimulation of a Markov model. In ...Continue Reading

References

Aug 26, 2000·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·S SharmaH Hollands
Jun 11, 2005·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Sanjay SharmaGaurav K Shah
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Citations

Jul 16, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·Gerardus Wj FrederixAnke M Hövels
Jun 13, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Alan F CruessDavid Wong
Jul 16, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Melissa M Brown, Gary C Brown
Nov 14, 2015·PharmacoEconomics·Jordana K Schmier, Carolyn K Hulme-Lowe
Sep 18, 2016·Applied Health Economics and Health Policy·Thomas ButtGary Rubin
Jan 19, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T LehnertH-H König
Aug 29, 2014·Organic & Biomolecular Chemistry·Bit LeeTimothy W Corson
Dec 4, 2019·Archivos de la Sociedad Española de Oftalmología·P V Muñoz-RamónF J Muñoz-Negrete

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