Pharmacologic management of the older patient with type 2 diabetes mellitus

The American Journal of Geriatric Pharmacotherapy
Joshua J Neumiller, Stephen M Setter

Abstract

Pharmacologic options for the treatment of elderly patients with type 2 diabetes mellitus (T2DM) are the same as in younger adults; however, treatment considerations differ in the elderly due to changes in renal and hepatic function, life expectancy, and various other clinical and practical considerations. This article discusses geriatric considerations in the pharmacologic management of T2DM and reviews the potential clinical advantages and disadvantages of pharmacologic agents currently available for the treatment of T2DM, including oral and injectable medications. A search of MEDLINE was conducted for articles published in English between January 1966 and September 2009 using the terms type 2 diabetes mellitus, elderly, geriatric, treatment, insulin, metformin, sulfonylurea, thiazolidinedione, alpha-glucosidase inhibitor, meglitinide, DPP-4 inhibitor, colesevelam, exenatide, and pramlintide. Meta-analyses, randomized controlled trials of pharmacologic treatment, and evidence-based reviews and/or expert opinions regarding the treatment of T2DM in the elderly were selected for review. In overweight patients, metformin has been associated with reductions in risk for all-cause mortality and stroke compared with insulin and sulfo...Continue Reading

References

Apr 1, 1985·Journal of the American Geriatrics Society·R D LindemanN W Shock
Sep 11, 1971·British Medical Journal·K O'MalleyI H Stevenson
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jun 1, 1995·Diabetes Research and Clinical Practice·C CoscelliG A Coronel
Jun 1, 1997·Journal of Clinical Epidemiology·T van StaaJ Monette
Oct 17, 1998·Diabetes Care·J B BrownP Latare
Nov 26, 1998·Drugs & Aging·K Turnheim
Sep 24, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A K BormP P Naworth
Jan 21, 2000·Drugs & Aging·M B Graal, B H Wolffenbuttel
Feb 19, 2002·Diabetes Research and Clinical Practice·M RezaT J Hendra
Jul 3, 2002·Annals of Internal Medicine·Dmitri KirpichnikovJames R Sowers
Aug 14, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M Korytkowski
Apr 16, 2003·Journal of the American Geriatrics Society·Arlene F BrownUNKNOWN California Healthcare Foundation/American Geriatrics Society Panel on Improving Care for Elders with Diabetes
Aug 17, 2004·The Medical Clinics of North America·Ralph A DeFronzo
Sep 10, 2004·The New England Journal of Medicine·Hannele Yki-Järvinen
Oct 27, 2004·Diabetes Care·John B BuseUNKNOWN Exenatide-113 Clinical Study Group
Dec 8, 2004·Experimental Gerontology·Klaus Turnheim
Jan 29, 2005·Diabetes Care·Philip RaskinUNKNOWN INITIATE Study Group
May 16, 2006·Journal of the American Medical Directors Association·Barbara J ZarowitzTerry O'Shea
Jul 19, 2006·Annals of Internal Medicine·Arshag D MooradianStewart G Albert
Sep 15, 2006·The Diabetes Educator·Peggy Soule OdegardJason L Iltz
Nov 1, 2006·International Journal of Clinical Practice·A Barnett
Apr 12, 2007·British Journal of Clinical Pharmacology·Helle LinnebjergRobert Lins
Sep 5, 2007·International Journal of Clinical Practice. Supplement·C Mathieu, K Bollaerts
Jun 30, 2007·Drugs·Bart Staels, Folkert Kuipers
Sep 13, 2007·JAMA : the Journal of the American Medical Association·A Michael LincoffSteven E Nissen
Sep 13, 2007·JAMA : the Journal of the American Medical Association·Sonal SinghCurt D Furberg
Sep 28, 2007·Drugs & Aging·Danelle CayeaSamuel C Durso
Oct 13, 2007·Expert Opinion on Pharmacotherapy·A Barnett
Dec 7, 2007·Annals of Internal Medicine·Daniel S BudnitzChesley L Richards
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Lorraine L LipscombeDavid A Alter
Jan 4, 2008·Expert Opinion on Drug Safety·Ann V Schwartz, Deborah E Sellmeyer

❮ Previous
Next ❯

Citations

Jul 24, 2012·Cancer Metastasis Reviews·María José Méndez-VidalRuth Viciana
Mar 14, 2012·Advances in Therapy·Giuseppe PaolissoEdoardo Mannucci
Oct 8, 2013·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Etie Moghissi
Nov 28, 2012·The Australian Journal of Rural Health·Liou Jyun-YouHsu Chao-Yu
Jul 7, 2011·Indian Journal of Endocrinology and Metabolism·Manash P BaruahFaruque Pathan
Feb 5, 2014·Internal Medicine·Yukinao SakaiShuichi Tsuruoka
Apr 30, 2014·Drugs & Aging·James R GavinKenneth E Truitt
Sep 10, 2013·Irish Journal of Medical Science·N L ZaharanK Bennett
May 8, 2013·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Angela ThompsonJoseph J Saseen
Feb 12, 2014·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Angela M ThompsonJoseph J Saseen
Apr 23, 2014·Current Diabetes Reports·John M MilesBarry A Borlaug
May 14, 2011·Expert Opinion on Pharmacotherapy·Lisa M YounkStephen N Davis
Mar 7, 2013·Expert Opinion on Drug Metabolism & Toxicology·André J Scheen
Jan 12, 2016·Canadian Journal of Diabetes·Mousumi SircarMedha Munshi
Jan 22, 2013·Revista española de geriatría y gerontología·Francesc Formiga, Leocadio Rodriguez Mañas
Jan 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ganesh V HaladeGabriel Fernandes
May 25, 2010·Revista española de geriatría y gerontología·Francesc Formiga
Oct 15, 2013·Diabetes/metabolism Research and Reviews·Arie Ben YehudaSamuel Durso
Jul 31, 2014·Diabetes, Obesity & Metabolism·W M Valencia, H Florez
May 24, 2014·Diabetes Research and Clinical Practice·Lillan Mo AndreassenReidun Lisbet Skeide Kjome
Dec 8, 2017·Journal of Therapeutic Ultrasound·Ivan Suarez CastellanosVesna Zderic
Jul 12, 2017·World Journal of Diabetes·Funda Datli Yakaryılmaz, Zeynel Abidin Öztürk
Apr 28, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Niyati Chiniwala, Serge Jabbour
Feb 9, 2012·Postgraduate Medicine·Richard E Pratley, Matthew Gilbert
Apr 23, 2014·Aging·Angela DardanoRoberto Miccoli
Jun 12, 2013·Postgraduate Medicine·George Grunberger
Feb 13, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Richard E PratleyMary Alice Miller
Feb 24, 2015··Wanda PrattPaula Lozano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

© 2021 Meta ULC. All rights reserved