Pharmacologic prevention of aspiration pneumonia: a systematic review

The American Journal of Geriatric Pharmacotherapy
Ali A El Solh, Ranime Saliba

Abstract

Aspiration pneumonia is a common cause of morbidity and mortality. Several approaches, including bed positioning, dietary changes, and oral hygiene, have been proposed to prevent aspiration pneumonia, yet few data are available on the efficacy of pharmacologic interventions in reducing the rate of aspiration. This study was a systematic literature review of the pharmacologic prevention of aspiration pneumonia. We searched MEDLINE (1996-2006); EMBASE (1974-2006); Cumulative Index to Nursing & Allied Health Literature (CINAHL) (1982-2006); Health Services Technology, Administration, and Research (HealthSTAR) (1975-2006); and the Cochrane Library for relevant articles. References of all included articles were reviewed. Studies were included if they had a prospective, controlled design with a primary outcome of prevention of aspiration pneumonia. Surrogate outcomes that had a direct link to decreasing the incidence of aspiration pneumonia were considered. Selected articles were reviewed independently by 2 authors. Of 1108 studies reviewed, 20 were analyzed. Angiotensin-converting enzyme inhibitors may be beneficial in selected patients at high risk for aspiration. Capsaicin may be a low-risk approach to stimulate swallowing and cou...Continue Reading

References

Dec 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Aug 1, 1991·The American Review of Respiratory Disease·A TorresR Rodriguez-Roisin
Jan 1, 1990·Dysphagia·M J FeinbergL Segall
Sep 1, 1990·British Journal of Pharmacology·M Ichinose, P J Barnes
Sep 1, 1988·Neurology·J HornerK N Chase
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·Y JinH Sasaki
May 1, 1994·Chest·H KobayashiH Sasaki
May 1, 1993·Chest·H NakazawaT Takishima
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·T EbiharaH Sasaki
Nov 9, 1996·Lancet·H KobayashiH Sasaki
Nov 23, 1996·Lancet·T E Finucane, J P Bynum
May 22, 1998·Chest·K NakayamaH Sasaki
Jul 8, 1998·Brain Injury : [BI]·R D ZafonteN R Mann
Jul 22, 1998·Lancet·T AraiH Fujiwara
Oct 6, 1998·Lancet·K SekizawaH Sasaki
Dec 24, 1998·Lancet·T AraiY Kashiki
Apr 21, 1999·Lancet·T NakagawaH Sasaki
Jun 17, 1999·Neurology·V S KosticS Przedborski
Aug 28, 1999·Lancet·T YoneyamaH Sasaki
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Feb 26, 2000·Journal of Internal Medicine·T NakagawaH Sasaki
Apr 4, 2000·British Medical Bulletin·D G Weir, J M Scott
Feb 24, 2001·Journal of the American Geriatrics Society·M YamayaH Sasaki
Mar 3, 2001·The New England Journal of Medicine·P E Marik
Mar 13, 2001·Journal of Public Health Dentistry·G W TaylorM S Terpenning
May 31, 2001·Journal of the American Geriatrics Society·M YamayaH Sasaki
Jul 10, 2001·American Journal of Public Health·W B BaineJ P Summe
Feb 15, 2002·Journal of the American Geriatrics Society·E SatoH Sasaki
Jul 2, 2003·Journal of the American Geriatrics Society·Mark B LoebCindy Walker-Dilks
Dec 23, 2003·Journal of the American Geriatrics Society·Tadashi AraiHisayoshi Fujiwara
Mar 3, 2004·American Journal of Respiratory and Critical Care Medicine·Takayoshi OhkuboUNKNOWN Perindopril Protection Against Recurrent Stroke Sutdy Collaborative Group
Mar 23, 2004·BMJ : British Medical Journal·Lorna MasonHenry J McQuay
May 27, 2004·Journal of the American Geriatrics Society·Mei HeHidetada Sasaki
Sep 29, 2004·Journal of the American Geriatrics Society·Takae EbiharaHidetada Sasaki
Oct 16, 2004·Respiratory Medicine·Ken OhtaNan-Shan Zhong
Mar 1, 2005·Drugs & Aging·Masayuki KikawadaMasaru Takasaki
May 10, 2005·Journal of the American Geriatrics Society·Takae EbiharaHidetada Sasaki
Jan 5, 2007·The New England Journal of Medicine·René SchadeEdeltraut Garbe

❮ Previous
Next ❯

Citations

Mar 12, 2009·Current Opinion in Pulmonary Medicine·Mateo Cabre
Feb 5, 2010·Journal of the American Medical Directors Association·Paul Drinka
Nov 17, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J S W LeeJ Woo
Nov 17, 2009·Revista española de geriatría y gerontología·Julia Barroso
Nov 13, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hitoshi MinakuchiHiroshi Itoh
Sep 7, 2016·Geriatrics & Gerontology International·Taro KojimaUNKNOWN Working Group on Guidelines for Medical Treatment and its Safety in the Elderly
May 24, 2018·Journal of Cachexia, Sarcopenia and Muscle·Riyo KomatsuMasakazu Ichinose
Aug 16, 2019·Geriatrics & Gerontology International·Mari YamasueJun-Ichi Kadota
Jul 6, 2018·Experimental Brain Research·Toshiro UmezakiShigeru Hirano
Apr 11, 2018·Pneumonia·Hirotaka NakashimaMasafumi Kuzuya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Geriatrics Society
Tadashi AraiHisayoshi Fujiwara
Journal of the American Geriatrics Society
Takeyoshi YoneyamaOral Care Working Group
The New England Journal of Medicine
P E Marik
Journal of the American Geriatrics Society
M S TerpenningW J Loesche
© 2021 Meta ULC. All rights reserved