Pharmacologic Properties of Novel Local Anesthetic Agents in Anesthesia Practice

Anesthesiology Clinics
Chih H KingRichard D Urman

Abstract

Therapeutic duration of traditional local anesthetics when used in peripheral nerve blocks is normally limited. This article describes novel approaches to extend the duration of peripheral nerve blocks currently available or in development. Three newer approaches on extending the duration of peripheral nerve blocks include site-1 sodium channel blockers, novel local anesthetics delivery systems, and novel adjuvants of local anesthetics. Compared with plain amide-based and ester-based local anesthetics, alternative approaches show significant promise in decreasing postoperative pain, rescue opioid requirement, hospital length-of-stay, and overall health care cost, without compromising the established safety profile of traditional local anesthetics.

Citations

Jul 26, 2017·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Alexander J KimRichard D Urman
Oct 23, 2018·Current Opinion in Anaesthesiology·Andrew Iskander, Tong J Gan
Jun 5, 2020·Circulation. Arrhythmia and Electrophysiology·Sharan Prakash SharmaDhanunjaya Lakkireddy
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Renê Oliveira do CoutoOsvaldo de Freitas
Apr 2, 2021·The Journal of Pharmacy and Pharmacology·Ying-Jen ChangChing-Hsia Hung

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