PMID: 1202171Dec 1, 1975Paper

Pharmacologic studies of Hirschsprung's disease on a murine model

Journal of Pediatric Surgery
J Richardson

Abstract

In studies of the pharmacology of a murine model of aganglionosis, the contracted aganglionic portion of the terminal bowel showed slow regular contractions of high amplitude in comparison to the rapid low-amplitude contractions of a normal segment of bowel. An absence of the nonadrenergic inhibitory system was demonstrated in the aganglionic, contracted portion of the bowel. This lack of the nonadrenergic system confirms previous findings in human tissue. It is proposed that absence of this inhibitory system in the aganglionic portion of the bowel results in the principal pathophysiologic findings in Hirschsprung's disease.

References

Mar 1, 1971·The Tohoku Journal of Experimental Medicine·A Rikimaru, T Suzuki
Feb 1, 1966·The Journal of Physiology·G BurnstockM J Rand
Sep 1, 1964·International Journal of Neuropharmacology·K A NORBERG

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Citations

May 1, 1993·World Journal of Surgery·P Puri
Oct 1, 2005·Pediatric Surgery International·Feilim Murphy, Prem Puri
Nov 1, 1982·Experimental Lung Research·L Diamond, J B Richardson
Jul 1, 1982·Acta paediatrica Scandinavica·A P ChandranL K Sharma
Jan 1, 1981·Lung·J B Richardson
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sean M WardKenton M Sanders
Jun 1, 1978·Current Problems in Surgery·W K Sieber

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