Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis

Canadian Journal of Kidney Health and Disease
Rosendo A RodriguezKevin D Burns

Abstract

Increased carotid-femoral pulse wave velocity (cf-PWV), a surrogate of increased aortic stiffness, is a risk factor for cardiovascular events and all-cause mortality in end-stage renal disease (ESRD). To minimize the deleterious effects of an increased aortic stiffness in ESRD patients, several interventions have been developed and cf-PWV has been used to monitor responses. The aim of this study was to determine the effects of pharmacologic interventions that target aortic stiffness on cf-PWV and systolic blood pressure (SBP) in adults with ESRD. This study implements a systematic review and meta-analysis. MEDLINE, EMBASE, Cochrane Central, Health Technology Assessment, and EBM databases were searched. Randomized and non-randomized studies involving adults (>18 years) with ESRD of any duration, receiving or not renal replacement therapy (hemodialysis, peritoneal dialysis) and exposed to a pharmacologic intervention whose effects were assessed by cf-PWV. Study screening, selection, data extraction, and quality assessments were performed by 2 independent reviewers. Narrative synthesis and quantitative data analysis summarized the review. We included 1027 ESRD participants from 13 randomized and 5 non-randomized studies. Most phar...Continue Reading

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Apr 2, 2021·Circulation Research·Pierre BoutouyrieGary F Mitchell

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