Pharmacologic treatment for postviral olfactory dysfunction: a systematic review

International Forum of Allergy & Rhinology
Lucas Harless, Jonathan Liang

Abstract

Postviral olfactory dysfunction (PVOD) is the most common cause of olfactory dysfunction. Several treatments have been presented in the literature. The objective of this study is to systematically review the existing literature on the effectiveness of pharmacologic treatments for PVOD. We performed a literature search of PubMed, Ovid, and ScienceDirect from 1966 to 2014. Inclusion criteria included English-language articles containing original data on pharmacologic treatment of PVOD with ≥5 subjects, measurable outcomes, and readily available treatments. Data was collected regarding study design, subject demographic information, clinical outcomes, and level of evidence. Two investigators reviewed all articles independently. Of 445 abstracts identified, 8 articles were included, yielding 563 patients. Treatments investigated included oral corticosteroids, local injections of corticosteroids, zinc sulfate, alpha lipoic acid, caroverine, vitamin A, Ginkgo biloba, and minocycline. Outcome measures were determined by symptom scores and objective olfactory test methods-the most common being Sniffin' Sticks. Improvement was noted in subjects receiving oral corticosteroid therapy, local injections of corticosteroid, alpha lipoic acid, ...Continue Reading

References

May 1, 1991·Archives of Otolaryngology--head & Neck Surgery·D A DeemsJ B Snow
Jan 8, 1999·Acta Oto-laryngologica. Supplementum·T AibaY Nakai
Aug 5, 2008·The Laryngoscope·Daron Cope, Ronaldo Bova
Aug 19, 2009·Annals of the New York Academy of Sciences·Howard J HoffmanBarry Davis
Oct 21, 2009·Archives of Otolaryngology--head & Neck Surgery·Beom Seok SeoJeong-Whun Kim
Nov 26, 2009·Rehabilitation Psychology·Monique A M SmeetsJan H A Kroeze
Aug 14, 2012·Rhinology·V A SchrieverT Hummel
Oct 12, 2013·Clinical Endocrinology·Damiano GulloRiccardo Vigneri
Oct 12, 2013·The Laryngoscope·Iordanis KonstantinidisJannis Constantinidis
Jun 3, 2015·The Laryngoscope·Aytug AltundagThomas Hummel

❮ Previous
Next ❯

Citations

Jul 9, 2016·International Forum of Allergy & Rhinology·Richard R Orlandi
Apr 10, 2020·International Forum of Allergy & Rhinology·Zachary M SolerEric H Holbrook
Jun 12, 2020·Head & Neck·Valeria Dell'EraMassimiliano Garzaro
Apr 30, 2020·International Forum of Allergy & Rhinology·Paolo CastelnuovoDimitri Rabbiosi
Jul 15, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nrusheel KattarEdward D McCoul
Jun 23, 2020·International Forum of Allergy & Rhinology·Nanki HuraNicholas R Rowan
Oct 23, 2020·Psychological Medicine·Romain ColleEmmanuelle Corruble
Mar 2, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yichen GuoYongxiang Wei
Jul 20, 2021·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Erkan YildizOrhan Kemal Kahveci
Sep 1, 2021·Ear, Nose, & Throat Journal·Hong-Gang DuanMao-Xiao Yan
Dec 11, 2021·Current Opinion in Otolaryngology & Head and Neck Surgery·Katerina KaramaliClaire Hopkins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.