PMID: 2479282Jan 1, 1989Paper

Pharmacological abnormalities in atopic dermatitis.

Allergy
J M Hanifin

Abstract

Numerous investigations have described cutaneous and systemic physiological and pharmacological aberrations in atopic dermatitis and the atopic diathesis. Some of these studies set the stage for a focus upon cyclic nucleotide abnormalities. Elevated leukocyte cyclic AMP-phosphodiesterase accounts for low intracellular cyclic AMP levels in atopic dermatitis. The resultant permissive effect correlates with abnormal functional parameters such as increased basophil histamine release and in vitro IgE synthesis. In vitro and clinical use of phosphodiesterase inhibitors corrects abnormal parameters and may indicate future therapeutic directions.

References

Jan 1, 1986·Archives of Dermatological Research·C Bruynzeel-KoomenP L Bruynzeel
Apr 1, 1988·The Journal of Experimental Medicine·D VercelliD Y Leung
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Apr 1, 1988·The Journal of Allergy and Clinical Immunology·H A Sampson
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·T A GiustinaJ M Hanifin
Sep 1, 1981·The Journal of Allergy and Clinical Immunology·M J SafkoJ M Hanifin
May 1, 1983·The Journal of Allergy and Clinical Immunology·J M ButlerJ M Hanifin
Mar 1, 1983·Journal of the American Academy of Dermatology·K KangJ M Hanifin

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Citations

Jan 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S P CollinsM E Howden

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