PMID: 2492627Jan 1, 1989Paper

Pharmacological action of the phospholipase A2 from the venom of Trimeresurus flavoviridis on the smooth muscle of the rat stomach

Life Sciences
K KamataY Samejima

Abstract

Phospholipase A2 (PLA2) from the venom of the snake Trimeresurus flavoviridis produced an increase in resting tension of isolated strips of rat stomach fundus. The contractions of the fundus strips induced by the PLA2 were significantly inhibited by treatment with 10(-6) M indomethacin and in Ca2+-free medium, while treatment of the fundus strips with nordihydroguaiaretic acid caused a marked potentiation of the PLA2-induced contraction. Atropine (10(-6) M), chlorpheniramine (10(-6) M) and methysergide (10(-6) M) had no effects on the contractions induced by PLA2, while tetrodotoxin (10(-6) M) significantly potentiated the contraction. From these results, it appears that exogenously applied PLA2 may cause contraction of the rat stomach fundus through the liberation of endogenous arachidonic acid which may then be transformed into prostaglandins.

References

Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·D Mebs, Y Samejima
Feb 1, 1953·Archives of Biochemistry and Biophysics·A L TAPPELP D BOYER
Sep 1, 1957·British Journal of Pharmacology and Chemotherapy·J R VANE

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Citations

May 27, 1992·European Journal of Pharmacology·C D SommersD W Snyder
Oct 16, 1999·Toxicon : Official Journal of the International Society on Toxinology·R YanoshitaY Samejima
Feb 13, 2001·Biochemical and Biophysical Research Communications·A G TemponeN Nascimento

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