PMID: 9194681Jan 1, 1997Paper

Pharmacological actions of melatonin in oxygen radical pathophysiology

Life Sciences
R J ReiterA Muñoz-Hoyos

Abstract

Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. This review briefly summarizes the published reports supporting this conclusion. Melatonin is believed to work via electron donation to directly detoxify free radicals such as the highly toxic hydroxyl radical. Additionally, in both in vitro and in vivo experiments, melatonin has been found to protect cells, tissues and organs against oxidative damage induced by a variety of free radical generating agents and processes, e.g., the carcinogen safrole, lipopolysaccharide, kainic acid, Fenton reagents, potassium cyanide, L-cysteine, excessive exercise, glutathione depletion, carbon tetrachloride, ischemia-reperfusion, MPTP, amyloid beta (25-35 amino acid residue) protein, and ionizing radiation. Melatonin as an antioxidant is effective in protecting nuclear DNA, membrane lipids and possibly cytosolic proteins from oxidative damage. Also, melatonin has been reported to alter the activities of enzymes which improve the total antioxidative defense capacity of the organism, i.e., superoxide dimutase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and nitric oxide synthase. Mos...Continue Reading

References

Oct 1, 1979·The Journal of Clinical Investigation·M S KlempnerJ I Gallin
Jan 1, 1975·Annual Review of Biochemistry·I Fridovich
Nov 17, 1992·Biochemical Pharmacology·A Meister
Mar 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R J Reiter
Jul 1, 1990·Archives of Biochemistry and Biophysics·B Halliwell, J M Gutteridge
Jan 1, 1990·Acta paediatrica Scandinavica·J K Lloyd
Mar 13, 1989·FEBS Letters·S BlountJ Lunec
Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Sep 30, 1985·Biochemical and Biophysical Research Communications·J Poirier, A Barbeau
Jun 1, 1985·British Heart Journal·M J O'HaraE B Raftery
Jan 1, 1994·Progress in Neurobiology·G Sperk
May 1, 1994·Journal of Vascular Research·W C Sessa
May 1, 1995·Experimental Gerontology·G Pierrefiche, H Laborit
Mar 1, 1995·Mutation Research·M L GarriottL S Schwier
May 31, 1994·Annals of the New York Academy of Sciences·R J ReiterS Saarela
Feb 1, 1994·Journal of Pharmaceutical Sciences·R T BlickenstaffR Witt
Jan 8, 1996·Toxicology·S Ivanović-Matić, G Poznanović
Dec 1, 1995·Free Radical Biology & Medicine·E SewerynekR J Reiter
Jun 15, 1996·Annals of the New York Academy of Sciences·R J ReiterJ M Guerrero
Mar 25, 1996·Molecular and Cellular Endocrinology·E SewerynekW M Daniels
Jun 1, 1996·Cardiovascular Research·S BertugliaA Colantuoni
Mar 1, 1996·Journal of Pineal Research·G J Maestroni
Apr 26, 1996·Biochemical Pharmacology·D MelchiorriG Nisticò
Dec 2, 2010·Japanese Journal of Clinical Oncology·Eiichiro SuzukiChigusa Morizane

❮ Previous
Next ❯

Citations

Aug 2, 2005·Bioelectromagnetics·Denis L Henshaw, Russel J Reiter
Sep 5, 2002·Journal of Neuroscience Research·Francisco Martinez-CruzJuan M Guerrero
Nov 22, 2001·Experimental Neurology·M C LeeS U Kim
Feb 13, 2001·Journal of Molecular and Cellular Cardiology·R SalieA Lochner
Nov 4, 2000·Journal of Biomedical Science·R J ReiterE Gitto
Jul 2, 2003·Neurotoxicity Research·C J van der SchyfN Castagnoli
Jun 22, 2006·Neurotoxicity Research·M F BealT Archer
Feb 11, 2005·Journal of Physiology and Biochemistry·M OgeturkM Sarsilmaz
Sep 9, 2004·Journal of Physiology and Biochemistry·J BarrenetxeJ A Martínez
May 16, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ghaffar ShokouhiW Jerry Oakes
Jun 20, 2008·Archives of Pharmacal Research·Ersin FadilliogluCebrail Gursul
Feb 18, 2004·Journal of Pediatric Surgery·E GittoB Zuccarello
Mar 24, 2004·Toxicon : Official Journal of the International Society on Toxinology·Abdel-Raheim M A MekiHamdy M Hassanein
Aug 15, 2001·European Journal of Pharmacology·A CruzP Montilla
Mar 20, 1999·Mutation Research· VijayalaxmiK S Kumar
Jun 5, 2002·Mechanisms of Ageing and Development·Russel J ReiterSusanne Burkhardt
Nov 27, 1999·Mechanisms of Ageing and Development·R J ReiterV Rouvier-Garay
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Pattipati S NaiduShrinivas K Kulkarni
Mar 10, 2001·Progress in Neurobiology·M Ugarte, N N Osborne
Oct 14, 1998·Progress in Neurobiology·R J Reiter
Jul 4, 1998·Toxicology Letters·D MelchiorriG Nisticò
Feb 14, 2002·Free Radical Biology & Medicine·Gamal H El-SokkaryRussel J Reiter
May 8, 1999·Free Radical Biology & Medicine·H HaK H Kim
Mar 17, 2000·Free Radical Biology & Medicine·C HsuJ E Casida
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P LissoniG Tancini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.