Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

Frontiers in Pharmacology
Javad Sharifi-RadMiquel Martorell

Abstract

Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: "Psoralidin" or "therapeutic effects" or "biological activity" or "Cullen corylifolium" in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers c...Continue Reading

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Citations

Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohd SaeedMousa Alreshidi
Jul 6, 2021·Frontiers in Pharmacology·Md Shahazul IslamJavad Sharifi-Rad
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Javad Sharifi-RadDaniela Calina

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Methods Mentioned

BETA
xenograft
transfection
fluorescence microscopy
flow cytometry
fluorescence-activated cell sorting

Software Mentioned

PSO

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