Pharmacological activities of some new polycyclic triazolopyrazolopyridazine derivatives

International Journal of Biological Macromolecules
Saleh A BahashwanIbrahim M S Bassati

Abstract

In continuation of our previous work, a novel series of polycyclic derivatives were synthesized and their anti-inflammatory, analgesic and antimicrobial activities were evaluated. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). Some of the newly compounds exhibited better biological and pharmacological activities than the reference controls with low toxicity (LD(50)). The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. The detailed synthesis, spectroscopic data, LD(50) and pharmacological activities of the synthesized compounds were reported.

References

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May 23, 2006·Bioorganic & Medicinal Chemistry·Abdel-Galil E AmrAbu El-Fotooh G Hammam
Jul 8, 2008·European Journal of Medicinal Chemistry·Abd El-Galil E AmrMohamed M Abdalla
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Mar 1, 2012·International Journal of Biological Macromolecules·Mohamed M AbdallaAbdullah M Al-Mohizea

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Citations

Dec 11, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A BahashwanAtef Kalmouch
Mar 19, 2013·International Journal of Biological Macromolecules·Naif O Al-HarbiAbd El-Galil E Amr
Sep 1, 2017·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Saleh A Bahashwan
Sep 24, 2021·Critical Reviews in Food Science and Nutrition·Esmaeil SheibaniHermann Ehrlich

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