PMID: 22358078Feb 24, 2012Paper

Pharmacological activity of salvinorin A, the major component of Salvia divinorum

Pharmacological Reports : PR
Joanna ListosSylwia Fidecka

Abstract

The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been historically used for divination and shamanism by the Mazatecs. Today, S. divinorum has become increasingly popular as a recreational drug for its hallucinogenic effects. The non-nitrogenous diterpene, salvinorin A, the major active component of S. divinorum, is responsible for the hallucinogenic effect of this plant. Here, we described the behavioral effects of salvinorin A in animals including the addictive, antinociception and antidepressant properties of the drug. The present paper also demonstrates the not well recognized (or unclear) mechanisms of action of salvinorin A. The last part of the paper presents information about the legal status of S. divinorum and its derivatives. Taking into account the increasing popularity and consumption of salvinorin A and S. divinorum today, it is important to collect all data on the pharmacological profile of this plant and its products.

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Citations

Jun 10, 2016·Bioanalysis·Cláudia MargalhoEugenia Gallardo
Oct 5, 2017·European Journal of Pain : EJP·U CoffeenF Pellicer
Nov 15, 2018·Assay and Drug Development Technologies·Kendy Eduardo UrdanetaDario Siniscalco
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna SocałaPiotr Wlaź
Dec 1, 2015·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Rathi MahendranMunidasa Winslow
Mar 30, 2018·The American Journal on Addictions·Joseph El-Khoury, Evelyne Baroud
Jul 20, 2017·Phytochemical Analysis : PCA·Seda Damla HatipogluGulacti Topcu
Feb 7, 2021·Pharmaceuticals·Andreia Machado Brito-da-CostaÁurea Madureira-Carvalho

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