PMID: 10530808Oct 26, 1999

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

Neuropharmacology
D D SchoeppJ A Monn

Abstract

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a recognized, but still relatively new area of excitatory amino acid research. Current understanding of the roles and involvement of mGlu receptor subtypes in physiological/pathophysiological functions of the central nervous system has been recently propelled by the emergence of various structurally novel, potent, and mGlu receptor selective pharmacological agents. This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents.

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Related Concepts

Proteins, Recombinant DNA
Receptors, Metabotropic Glutamate
Entire Central Nervous System
Excitatory Amino Acid Antagonists
GTP-Binding Proteins
GRM1
Glutamate Agonists
Amino Acid [EPC]
Glutamate
Pharmacology

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