Pharmacological alteration of antigen-induced contraction of lung parenchymal strips isolated from the actively sensitized guinea pig

European Journal of Pharmacology
V SongsiridejC K Buckner


Several drugs, known to influence the action or formation of histamine and SRS-A, were examined for their abilities to alter antigen (ovalbumin)-induced contractions of guinea-pig isolated lung parenchymal strips. Cumulative dose-response effects of ovalbumin were obtained on paired parenchymal strips, one used as control and the other drug treated. When used alone, mepyramine, 10(-6) M, phenoxybenzamine, 3 x 10(-5) M and FPL55712, 10(-5) M, did not alter ovalbumin-induced contractions, 5,8,11,14-eicosatetraynoic acid (ETYA), 10(-4) M, produced a small (2.5-fold) rightward shift of the dose-response curves to ovalbumin and histamine. Indomethacin, 5 x 10(-6) M, produced a small increase in the maximum response to ovalbumin and a small (2-fold) rightward shift of the histamine dose-response curve. The effect of indomethacin on ovalbumin-induced contraction was not seen in the presence of phenoxybenzamine and may therefore be due to an increase in histamine release. Combination of indomethacin with FPL55712 or ETYA did not alter antigen-induced contractions. The effect of ETYA on the histamine dose-response curve was not seen in the presence of indomethacin. Combination of phenoxybenzamine with FPL55712 or ETYA caused a marked re...Continue Reading


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