Pharmacological analysis of diisopropyl fluorophosphate: effects on core temperature, heart rate, and motor activity in the unrestrained rat

Pharmacology, Biochemistry, and Behavior
C J Gordon

Abstract

Humans acutely exposed to anticholinesterase (anti-ChE) pesticides often become febrile, whereas rats and other rodents become markedly hypothermic. The rat may nonetheless be a useful model for anti-ChE toxicity because recent work using radiotelemetry demonstrated an elevation in core temperature of unrestrained rats for several days following acute exposure to the anti-ChE, diisopropyl fluorophosphate (DFP). To discern the mechanisms of DFP-induced hypothermia and hyperthermia, various pharmacological agents were administered acutely or chronically to rats injected with 1.5 mg/kg DFP (SC). Core temperature, heart rate, and motor activity were monitored continuously via radiotelemetry. Methylscopolamine, a peripheral muscarinic antagonist, attenuated the DFP-induced hypothermia by 1.0 degree C and reversed the DFP-induced bradycardia. Chronic scopolamine, a central and peripheral muscarinic antagonist, delivered via a subcutaneously implanted minipump (9.5 mg/kg/day) blocked DFP-induced hypothermia and hyperthermia. Propranolol (10 mg/kg; SC), a general beta blocker, augmented the bradycardic effects of DFP but had no effect on body temperature. Sodium salicylate (200 and 300 mg/kg; IP), an antipyretic that inhibits prostagla...Continue Reading

References

Jan 1, 1992·Critical Reviews in Biotechnology·S Chapalamadugu, G R Chaudhry
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·R P MaickelM B Nichols
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C B Matthew
Oct 1, 1987·Journal of Neurochemistry·M ReichmanL E Hokin
Jan 1, 1986·Physiology & Behavior·R SingerM J Kluger
Jan 1, 1985·Progress in Neurobiology·M J Dascombe
Apr 1, 1971·The American Journal of Medicine·T NambaD Grob
Aug 1, 1968·European Journal of Pharmacology·E Meeter, O L Wolthuis
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·C C LoullisR T Bartus

❮ Previous
Next ❯

Citations

Sep 5, 1997·Toxicology·P Johnson Rowsey, C J Gordon
Jan 11, 2003·Journal of Toxicology and Environmental Health. Part a·Christopher J Gordon, Cina M Mack
Mar 11, 1998·Clinical and Experimental Pharmacology & Physiology·C J Gordon, P J Rowsey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.