Pharmacological analysis of inhomogeneous static magnetic field-induced antinociceptive action in the mouse

Bioelectromagnetics
Klára GyiresJ F László

Abstract

The effect of inhomogeneous, 2-754 mT static magnetic field (SMF) on visceral pain elicited by intraperitoneal injection of 0.6% acetic acid (writhing test) was studied in the mouse. Exposure of mice to static magnetic field (permanent NdFeB N50 grade 10 mm x 10 mm cylindrical magnets with alternating poles) during the nociceptive stimulus (0-30 min) resulted in inhibition of pain reaction: the number of writhings decreased from 9 +/- 2, 32 +/- 4 and 30 +/- 3 to 2 +/- 0.03, 15 +/- 1.6, and 14 +/- 1.6, respectively, measured in 0-5th, 6-20th, and 21-30th min following the acetic acid challenge. The pain reaction during the total observation period was reduced by 57% (P < 0.005). The analgesic action induced by SMF was inhibited by subcutaneous administration of naloxone (1 and 0.2 mg kg(-1)), irreversible micro-opioid receptor antagonist beta-funaltrexamine (20 mg kg(-1)) and delta-opioid receptor antagonist naltrindole (0.5 mg kg(-1)), but the kappa-opioid receptor antagonist norbinaltorphimine (20 mg kg(-1)) failed to affect the SMF-induced antinociception. In contrast to the subcutaneous administration, the intracerebroventricularly injected naloxone (10 microg mouse(-1)) did not antagonize the antinociceptive effect of SMF. ...Continue Reading

References

Nov 1, 1992·Pain·Howard B GutsteinHuda Akil
Dec 5, 1994·Neuroscience Letters·C BetancurE Alleva
Jul 1, 1997·The Journal of Clinical Investigation·P J CabotC Stein
Oct 18, 2000·Pediatric Neurology·R R HolcombM J McLean
Mar 15, 2001·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·A P AlfanoG T Gillies
Dec 26, 2002·American Journal of Obstetrics and Gynecology·Candace S BrownArthur A Pilla
Feb 1, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Nicola SmaniaMichele Tinazzi
Aug 30, 2003·Behavioural Brain Research·Cristina Del SeppiaSergio Ghione
Jan 27, 2005·Bioelectromagnetics·Frank S PratoAlex W Thomas
May 12, 2005·Bioelectromagnetics·Venkatachalam Senthil KumarRengarajulu Puvanakrishnan
Jun 14, 2006·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·N M ShupakAlex W Thomas
Jul 27, 2007·Bioelectromagnetics·János LászlóKlára Gyires

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Citations

Dec 23, 2009·The Clinical Journal of Pain·János László, Natalia Pivec
Nov 19, 2013·Progress in Biophysics and Molecular Biology·Shuguang Yu, Peng Shang
Jun 21, 2013·Electromagnetic Biology and Medicine·Sebastian SzajkowskiJoanna Lewin-Kowalik
Oct 2, 2009·Peptides·Richard J Bodnar
Mar 21, 2012·Bioelectromagnetics·Hideyuki OkanoHozumi Tatsuoka
Jan 13, 2011·Bioelectromagnetics·Zsófia Kovács-BálintIstván Hernádi
Oct 13, 2009·Bioelectromagnetics·János László, József Kutasi
Jun 28, 2011·American Journal of Obstetrics and Gynecology·János F László, Róbert Pórszász
Dec 2, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sladjana SpasićDajana Todorović
Jul 10, 2016·Computer Methods and Programs in Biomedicine·Srdjan Kesić, Sladjana Z Spasić
Jun 18, 2009·Orvosi hetilap·János László
Jan 29, 2021·Bioelectromagnetics·Yixiang FanXin Zhang

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