Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfactory bulb

PloS One
Rico Tabor, Rainer W Friedrich

Abstract

Although synaptic functions of ionotropic glutamate receptors in the olfactory bulb have been studied in vitro, their roles in pattern processing in the intact system remain controversial. We therefore examined the functions of ionotropic glutamate receptors during odor processing in the intact olfactory bulb of zebrafish using pharmacological manipulations. Odor responses of mitral cells and interneurons were recorded by electrophysiology and 2-photon Ca(2+) imaging. The combined blockade of AMPA/kainate and NMDA receptors abolished odor-evoked excitation of mitral cells. The blockade of AMPA/kainate receptors alone, in contrast, increased the mean response of mitral cells and decreased the mean response of interneurons. The blockade of NMDA receptors caused little or no change in the mean responses of mitral cells and interneurons. However, antagonists of both receptor types had diverse effects on the magnitude and time course of individual mitral cell and interneuron responses and, thus, changed spatio-temporal activity patterns across neuronal populations. Oscillatory synchronization was abolished or reduced by AMPA/kainate and NMDA receptor antagonists, respectively. These results indicate that (1) interneuron responses de...Continue Reading

References

Aug 1, 1990·Journal of Neurophysiology·P Q Trombley, G L Westbrook
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·M E HasselmoJ M Bower
Aug 1, 1988·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·W B Mathieson, L Maler
Jun 1, 1994·Journal of Neurophysiology·D A BerkowiczG M Shepherd
Jul 1, 1997·Neuroscience·V Aroniadou-AnderjaskaM T Shipley
Jan 9, 1998·Progress in Neurobiology·P Duchamp-Viret, A Duchamp
May 15, 1998·Neuron·J S Isaacson, B W Strowbridge
Jul 13, 1999·Journal of Neurophysiology·V Aroniadou-AnderjaskaM T Shipley
Aug 13, 1999·Journal of Neurophysiology·A Y HsiaP M Lledo
Jan 29, 2000·Brain Research·D A Berkowicz, P Q Trombley
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·G GheusiP M Lledo
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·J S Isaacson
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·A DidierP M Lledo
Oct 16, 2002·Nature Neuroscience·Nathan E Schoppa, Gary L Westbrook
Nov 5, 2002·Nature Reviews. Neuroscience·Gilles Laurent
Nov 21, 2002·The Journal of Comparative Neurology·Jeffrey G Edwards, William C Michel
Apr 25, 2003·Journal of Neurophysiology·Brian Halabisky, Ben W Strowbridge
Aug 22, 2003·Journal of Neurophysiology·Shin-ichi HigashijimaJoseph R Fetcho
Dec 12, 2003·Nature·J L AungstM T Shipley
Feb 13, 2004·Journal of Neurophysiology·Rainer W Friedrich, Gilles Laurent
Mar 30, 2004·Chemical Senses·A M McNamaraC Linster
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samuel LagierPierre-Marie Lledo
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matt WachowiakRainer W Friedrich
Jul 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rico TaborRainer W Friedrich
Jul 27, 2004·Nature Neuroscience·Rainer W FriedrichGilles Laurent
Dec 8, 2004·The European Journal of Neuroscience·Patrizia PanzanelliMarco Sassoè-Pognetto
Feb 8, 2005·Nature Neuroscience·Gabe J MurphyJeffry S Isaacson
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Veronica EggerZachary F Mainen
Jun 1, 2005·Neuron·Jason M ChristieGary L Westbrook
Jun 17, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun LiRainer W Friedrich
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tibor ZellesKerry R Delaney

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Citations

Aug 28, 2014·Neuroreport·Birbickram Roy, Declan W Ali
Aug 29, 2009·Journal of Computational Neuroscience·Stuart D WickHermann Riecke
Jun 4, 2013·Annual Review of Neuroscience·Rainer W Friedrich
Jun 10, 2014·FEBS Letters·Rainer W Friedrich, Martin T Wiechert
Sep 24, 2009·Expert Opinion on Drug Discovery·Su Guo
Sep 13, 2011·Neurotoxicology and Teratology·E P RicoC D Bonan
Nov 28, 2009·Brain Research Bulletin·Eduardo Pacheco RicoMaurício Reis Bogo
Aug 19, 2009·Annals of the New York Academy of Sciences·Rainer W FriedrichMartin T Wiechert
Jul 12, 2008·The European Journal of Neuroscience·Rico TaborRainer W Friedrich
Nov 15, 2011·Nature·Francisca BlumhagenRainer W Friedrich
Jan 26, 2011·PloS One·Hiroshi BandohHiroshi Ueda
Feb 28, 2020·Neurochemistry International·Francini FranscesconDenis B Rosemberg

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Methods Mentioned

BETA
transgenic

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Matlab
CFNT

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