Pharmacological analysis of the CCKB/gastrin receptors mediating pentagastrin-stimulated gastric acid secretion in the isolated stomach of the immature rat

British Journal of Pharmacology
D M HillsJ W Black

Abstract

1. The CCKB/gastrin receptors mediating pentagastrin stimulation of gastric acid secretion by histamine release and by direct stimulation of oxyntic cells have been characterized in the immature rat isolated stomach assay. This was achieved by estimating antagonist affinity values for competitive antagonists from three distinct chemical classes (L-365,260, PD134,308 and JB93190) in the absence and presence of a high concentration of the histamine H2-receptor antagonist, famotidine (30 microM). 2. Pentagastrin produced concentration-dependent stimulation of gastric acid secretion in the absence and presence of famotidine. Famotidine depressed the maximum secretory response to pentagastrin although the degree of depression varied between experimental replicates (25-60%). This variation was attributed to the histamine-release mediated component of acid secretion, as judged by the consistency of the maximum responses obtained in the presence, but not absence, of famotidine. 3. All three CCKB/gastrin receptor antagonists behaved as surmountable antagonists in the absence and presence of famotidine. JB93190 (pKB approximately 9.1, approximately 8.9, in the absence and presence of famotidine, respectively) was approximately 30 fold mo...Continue Reading

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Citations

Jul 17, 1999·European Journal of Pharmacology·C BlandizziM Del Tacca
Dec 21, 2002·Life Sciences·F Borrelli, I A Tavares
Jun 29, 1999·British Journal of Pharmacology·E LindströmR Håkanson
Apr 6, 2002·British Journal of Pharmacology·Maristella AdamiGiulio Soldani
Sep 30, 2000·Alimentary Pharmacology & Therapeutics·F BorrelliI A Tavares
Jun 21, 2017·European Journal of Pharmacology·Cheng-Yuan LiYun-Man Li
Jul 20, 2007·Phytotherapy Research : PTR·Fatemeh Nabavizadeh RafsanjaniMohammad Vahedian Ardakani
Nov 2, 2019·Physiological Reviews·Amy C EngevikJames R Goldenring
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel
Oct 12, 2017·Frontiers in Physiology·Rosa M ArinBegoña Ochoa

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