Pharmacological analysis of the inhibition by pirenzepine and atropine of vagal-stimulated acid secretion in the isolated stomach of the mouse

British Journal of Pharmacology
J W Black, N P Shankley

Abstract

The muscarinic receptors involved in the vagal stimulation of gastric acid secretion in the mouse isolated stomach assay have been examined by analysing the effects of pirenzepine and atropine on fully-defined frequency-effect curves. Both atropine and pirenzepine produced concentration-dependent inhibition of vagal-stimulated acid secretion in a manner consistent with a model describing competitive antagonism of endogenous acetylcholine, which was assumed to be released by vagal stimulation. The results obtained are quite compatible with the hypothesis that vagal stimulation involves muscarinic receptors which are homogeneous with those previously found on histamine and oxyntic cells in the mouse stomach assay. These results find no evidence for muscarinic receptor heterogeneity and reinforce the hypothesis that the selectivity of pirenzepine in vivo relative to atropine is due to the loss of atropine into the gastric secretion.

References

Nov 1, 1985·British Journal of Pharmacology·J W Black, N P Shankley
Nov 1, 1985·British Journal of Pharmacology·J W BlackN P Shankley
Nov 1, 1985·British Journal of Pharmacology·J W Black, N P Shankley
Sep 1, 1985·British Journal of Pharmacology·R U ClagueR L Whiting
Dec 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J W Black, P Leff
Dec 1, 1982·British Journal of Pharmacology·I Szelenyi
Jan 1, 1980·British Journal of Pharmacology·D A BrownS Marsh
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

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Citations

Oct 26, 1988·European Journal of Pharmacology·S B FreedmanE A Harley
Jan 1, 1991·Trends in Pharmacological Sciences·W Kromer
Jan 1, 1993·General Pharmacology·A T OzçelikayY Oztürk
Nov 1, 1990·Journal of Pharmacological Methods·A T OzçelikayV M Altan
Nov 13, 2007·Ecotoxicology and Environmental Safety·Ryan P JonesJohn H Rodgers
May 23, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D M Quastel

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