PMID: 7537595Feb 1, 1995Paper

Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo

British Journal of Pharmacology
A LecciC A Maggi

Abstract

1. The topical application of bradykinin (BK) (0.05-5000 pmol/rat) onto the serosal surface of the urinary bladder in urethane-anaesthetized rats, evoked low amplitude tonic contractions (not exceeding 25 mmHg) or high amplitude (about 50 mmHg), phasic reflex contractions (chemoceptive micturition reflex) which were abolished by bilateral ablation of the pelvic ganglia. In ganglionectomized rats, BK induced only a local, tonic-type contraction. 2. Systemic capsaicin pretreatment (164 mumol kg-1, 4 days before) reduced the incidence of chemoceptive reflex induced by BK (500 pmol/rat) but had no effect on the magnitude of the tonic-type contraction elicited by BK in ganglionectomized rats. Indomethacin (11 mumol kg-1, 20 min before) reduced the incidence but not the amplitude of the reflex contractions induced by topical application of BK (500 pmol/rat). In ganglionectomized rats, indomethacin (11 mumol kg-1, 20 min before) decreased the amplitude of the tonic contraction evoked by BK. Indomethacin did not affect the chemoceptive reflex induced by topical application of capsaicin (15 nmol/rat) onto the bladder. 3. Intrathecal administration of the tachykinin NK1 receptor antagonists, RP 67,580 (10 nmol/rat) or SR 140,333 (10 nmol...Continue Reading

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F M CorrêaS H Snyder
Nov 1, 1992·Pharmacology & Therapeutics·J M Hall
Mar 1, 1991·British Journal of Pharmacology·K WirthJ Knolle
Sep 4, 1992·European Journal of Pharmacology·V Chapman, A H Dickenson
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C GarretP M Laduron
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L R SterankaS H Snyder
Mar 15, 1988·European Journal of Pharmacology·Y FujiwaraH I Yamamura
Jan 12, 1988·European Journal of Pharmacology·C A MaggiA Meli
May 15, 1988·Biochemical Pharmacology·N B Oza
Mar 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·C A MaggiA Meli
Jan 1, 1983·General Pharmacology·F MarceauJ P Giroud
Aug 3, 1984·European Journal of Pharmacology·C A MaggiA Meli
Oct 1, 1984·Journal of Neurochemistry·D C Perry, S H Snyder
Mar 1, 1993·Trends in Neurosciences·A Dray, M Perkins
Aug 1, 1993·Trends in Pharmacological Sciences·A Dray, S Bevan
Jan 1, 1993·Agents and Actions. Supplements·K M HargreavesJ Q Swift
Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·C A MaggiS Guliani

❮ Previous
Next ❯

Citations

Sep 11, 2002·European Journal of Pharmacology·Clare Davis, Gillian Burgess
Feb 10, 2000·European Journal of Pharmacology·S MeiniA Lecci
Sep 2, 1998·British Journal of Pharmacology·S GiulianiC A Maggi
Feb 5, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Peter OchodnickýMartin C Michel
Jan 27, 2009·European Journal of Pharmacology·Alexander McNamaraSharath S Hegde
Dec 21, 2006·British Journal of Pharmacology·F BellucciS Meini
Nov 16, 2004·European Journal of Pharmacology·Dinesh SrinivasanAnindya Bhattacharya
Jul 2, 2011·Biological & Pharmaceutical Bulletin·Naoko ShimizuKunio Ishii

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.