Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists

ACS Chemical Neuroscience
Rosana LeivaSantiago Vázquez

Abstract

This work reports the synthesis and pharmacological and electrophysiological evaluation of new N-methyl-d-aspartic acid receptor (NMDAR) channel blocking antagonists featuring polycyclic scaffolds. Changes in the chemical structure modulate the potency and voltage dependence of inhibition. Two of the new antagonists display properties comparable to those of memantine, a clinically approved NMDAR antagonist.

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Citations

Apr 3, 2020·Pharmaceutics·Júlia Companys-AlemanyChristian Griñán-Ferré
May 7, 2021·Journal of Medicinal Chemistry·Samuel ObengChristopher R McCurdy
Jul 16, 2021·Journal of Medicinal Chemistry·Samuel ObengChristopher R McCurdy

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