Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
A Q GuimarãesA Lôbo de Araújo

Abstract

Bothrops venoms cause local edema, pain, hemorrhage and necrosis. In this study, we investigated the ability of Bothrops lanceolatus venom to cause edema in rat hind paws and examined the mediators involved. Hind paw edema was induced in male Wister rats by the subplantar injection of venom (12.5-100 microg/paw) in the absence and presence of antagonists. Edema was quantified by hydroplethysmometry at 0.25, 0.5, 2, 4, 6 and 24 h post-injection and was expressed as the percentage increase relative to the contralateral (control) paw. The ability of the venom to release histamine from rat peritoneal mast cells was also assessed. Venom caused dose- and time-dependent edema that was maximal within 15 min but disappeared after 24 h and was accompanied by hemorrhage. Dexamethasone (1 mg/kg, s.c.), methysergide (6 mg/kg, i.p.), HOE 140 (0.6 mg/kg, i.v.) and mepyramine (6 mg/kg, i.p.) significantly ( p < 0.05) reduced edema formation, whereas indomethacin (10 mg/kg, i.p.) was ineffective. Dialysis did not affect venom-induced edema. Venom (1, 10 and 30 microg/ml) caused a concentration-dependent release of histamine (13 +/- 1%, 61.9 +/- 4.6% and 73.6 +/- 2.4%, respectively; n = 5) from rat peritoneal mast cells in vitro. Histological an...Continue Reading

Citations

Dec 7, 2002·Toxicon : Official Journal of the International Society on Toxinology·Vanessa Alves ArrudaAlbetiza Lôbo de Araújo
Sep 17, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Juliana P ZulianiFábio H Kwasniewski
Aug 4, 2009·Toxicon : Official Journal of the International Society on Toxinology·Bianca Cestari ZycharLuis Roberto C Gonçalves
Aug 26, 2009·Toxicon : Official Journal of the International Society on Toxinology·Neide Galvão NascimentoCatarina Teixeira
Nov 11, 2008·Toxicon : Official Journal of the International Society on Toxinology·Tatiane FerreiraElen C T Landucci
Mar 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Alessandra StrokaAlbetiza Lôbo de Araújo
Aug 17, 2014·Toxicon : Official Journal of the International Society on Toxinology·C W S WanderleyR C P Lima-Júnior
Aug 16, 2011·Toxicon : Official Journal of the International Society on Toxinology·Valéria Barbosa-SouzaMaria Alice da Cruz-Höfling
Nov 20, 2012·Toxicon : Official Journal of the International Society on Toxinology·Cristina HerreraJosé María Gutiérrez
May 19, 2017·Inflammopharmacology·José Carlos Tavares CarvalhoMaria Lúcia Silva
Sep 19, 2018·The American Journal of Tropical Medicine and Hygiene·M SeverynsJ L Rouvillain
Nov 22, 2017·PLoS Neglected Tropical Diseases·Luciana Lyra Casais-E-Silva, Catarina Teixeira
Dec 6, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N T Q AlvesH S A Monteiro
Oct 2, 2019·Frontiers in Immunology·Catarina TeixeiraAna Marisa Chudzinski-Tavassi
Jan 6, 2021·Archives of Toxicology·Felipe Silva de FrançaDenise V Tambourgi

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