Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure-Activity Relationships

Molecular Nutrition & Food Research
Jing-Jing Zhu, Jian-Guo Jiang

Abstract

Coumarins are fused benzene and pyrone ring systems with a wide spectrum of bioactivities, including antitumor, anti-inflammation, antiviral, and antibacterial effects. In this paper, the current development of coumarin-based drugs is introduced, and their structure-activity relationship is discussed by reviewing the relevant literature published in the past 20 years. Coumarin molecules can be customized by the target site to prevent systemic side effects by virtue of structural modification. The ortho-phenolic hydroxyl on the benzene ring has remarkable antioxidant and antitumor activities. Coumarins with aryl groups at the C-4 position have good activities in anti-HIV, antitumor, anti-inflammation, and analgesia. C-3 phenylcoumarins have strong anti-HIV and antioxidant effects. Tetracycline pyranocoumarins can significantly inhibit HIV; osthol structural analogues have antimicrobial activity. Praeruptorin C and its derivatives play an important role in lowering blood pressure and dilating coronary arteries, and khellactone derivatives have significant inhibitory effects on AIDS, cancer, and cardiovascular diseases. It is concluded that the specific site on the core structure of coumarin exhibits one or more activities due to ...Continue Reading

References

Jun 1, 1999·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·O Kayser, H Kolodziej
Oct 26, 1999·Bioorganic & Medicinal Chemistry·S SardariM Daneshtalab
Jun 18, 2002·Cancer Letters·Chau Jong WangTsui Hwa Tseng
Oct 26, 2002·Biopolymers·Hassan Y Aboul-EneinTeresa Michalska
Nov 14, 2002·Journal of Agricultural and Food Chemistry·Kumudini M MeepagalaDavid E Wedge
Nov 27, 2002·Planta medica·Hyoung Ja KimYong Sup Lee
Jul 25, 2003·European Journal of Pharmacology·Jimmy Yiu-Cheong WuHon-Yeung Cheung
Jan 27, 2004·Bioorganic & Medicinal Chemistry Letters·Christos A Kontogiorgis, Dimitra J Hadjipavlou-Litina
Apr 28, 2004·European Journal of Medicinal Chemistry·Mario Di BraccioGiuliana Leoncini
Jun 26, 2004·The Journal of Biological Chemistry·Rocío SanchoEduardo Muñoz
Jul 6, 2004·Journal of Ethnopharmacology·Xiang Lan PiaoJeong Hill Park
Apr 6, 2005·Bioorganic & Medicinal Chemistry·Natala Srinivasa ReddyM V Ramana Reddy
Aug 3, 2005·Journal of Computer-aided Molecular Design·Philip Prathipati, Anil K Saxena
Sep 3, 2005·Bioorganic & Medicinal Chemistry Letters·Luis M BedoyaJosé Alcamí
Dec 1, 2005·Phytotherapy Research : PTR·Michael Stavri, Simon Gibbons
Jan 3, 2006·Journal of Molecular Graphics & Modelling·Frank U AxeSándor Szalma
Jun 24, 2006·Bioorganic & Medicinal Chemistry Letters·Seokjoon LeeQian Wang
Jul 18, 2006·Current HIV Research·Irena Kostova
Feb 3, 2007·Medicinal Chemistry·Toshihiro OkamotoShinichi Yoshida
Dec 7, 2007·The Journal of Pharmacy and Pharmacology·Jens Z PedersenLuciano Saso
Dec 7, 2007·Bioorganic & Medicinal Chemistry·Mauro MazzeiRoberta Loddo
Jan 1, 2008·Bioorganic & Medicinal Chemistry Letters·Adeline BeillerotDenyse Bagrel

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Citations

May 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz KubrakAnna Bogucka-Kocka
May 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Verena Spiegler
Jul 28, 2020·Cancers·Esra Küpeli AkkolRaffaele Capasso
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chien-Ming LiuYi-Hsien Hsieh
Jul 3, 2020·International Journal of Molecular Sciences·Francesca AnnunziataAndrea Pinto
Oct 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anja HartmannHermann Stuppner
Oct 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin Kyu Kang, Chang-Gu Hyun
Jul 28, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Anastasia De LucaLuisa Rossi
Sep 6, 2020·Bioorganic Chemistry·Tarfah Al-WarhiWagdy M Eldehna
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Ana Sanches SilvaSeyed Mohammad Nabavi
May 7, 2019·Journal of Biophotonics·Piotr HanczycPiotr Fita
Dec 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesca PreziusoSerena Fiorito
Apr 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yanbei TuChengwei He
Jun 3, 2021·International Journal of Molecular Sciences·Jasmin FlemmingMatthias Hannig
Jul 6, 2021·Chemical Communications : Chem Comm·Jinhu XiYangjie Wu
Aug 12, 2021·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Mingna SunJianye Zhang

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