PMID: 9547855Apr 21, 1998Paper

Pharmacological and toxicological effects of chronic porcine growth hormone administration in dogs

Toxicologic Pathology
S PrahaladaM J van Zwieten

Abstract

The purpose of this study was to evaluate the pharmacological and toxicological effects of exogenous GH administration in normal adult dogs. Because porcine GH (pGH) is structurally identical to canine GH, pGH was selected for a 14-wk study in dogs. Thirty-two dogs (< 2 yr) were randomized to 4 groups (4 dogs/sex/group); 1 group was treated with the vehicle and 3 groups received pGH at 0.025, 0.1, or 1.0 IU/kg/day subcutaneously. Daily clinical signs and weekly body weights were recorded. Hematology, serum biochemistry, urinalyses, electrocardiograms, and ophthalmoscopic examinations were done. Serum GH, insulin-like growth factor-1 (IGF-1), insulin, thyroxine (T4), triiodothyronine (T3), and cortisol levels were determined. Necropsies were performed, organs weighed, and tissues were fixed and processed for light microscopic examination. Porcine GH caused increased body weight gain (p < or = 0.05) through the mid dose; the mean weight gains at study termination in mid- and high-dose groups were 2.8 kg and 4.7 kg, respectively, compared to 0.4 kg and 0.8 kg in control and low-dose groups, respectively. Dose-related increased weights of liver, kidney, thyroid, pituitary gland, skeletal muscle, and adrenal gland were noted. In pGH...Continue Reading

References

Apr 1, 1975·Diabetes·J M Sloan, I M Oliver
Jan 1, 1992·Hormone Research·J O JørgensenJ S Christiansen
Jan 1, 1972·Calcified Tissue Research·W H HarrisE H Weinberg
Jan 1, 1972·Calcified Tissue Research·R P HeaneyE H Weinberg
Jul 1, 1984·The Veterinary Clinics of North America. Small Animal Practice·J E Eigenmann
Jun 10, 1994·Gene·J A Ascacio-Martínez, H A Barrera-Saldaña
Apr 21, 1998·Toxicologic Pathology·S Molon-NoblotM J van Zwieten

❮ Previous
Next ❯

Citations

Dec 14, 1999·The Journal of Investigative Dermatology·R WankeE Wolf
Oct 7, 2008·The Veterinary Journal·Annemarie R VegterArnold A Stokhof
Feb 14, 2006·Domestic Animal Endocrinology·F FracassiH S Kooistra
Jul 20, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Amber R Buz'ZardBenjamin H S Lau
Jul 6, 2014·The Veterinary Journal·F FracassiM Caldin
Dec 25, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ruxandra Draghia-AkliRobert H Carpenter
May 9, 2014·Veterinary Pathology·C N Grimes, M M Fry
Aug 10, 2000·Toxicologic Pathology·S Molon-NoblotM J van Zwieten
Apr 21, 1998·Toxicologic Pathology·S Molon-NoblotM J van Zwieten
Apr 21, 1998·Toxicologic Pathology·C A Bondy
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Eckhardt S FerdinandiPascal Dubreuil
Dec 5, 2003·Veterinary Clinical Pathology·J P BraunA D J Watson
Apr 10, 2004·Cancer Gene Therapy·Catherine M ToneRuxandra Draghia-Akli
Dec 13, 2003·Endocrine Reviews·Stephanie R EdmondsonChristopher J Wraight
Mar 9, 2019·International Journal of Toxicology·Zaher A Radi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.