Pharmacological approaches for the treatment of obesity

Drugs
José-Antonio Fernández-LópezMarià Alemany

Abstract

The high incidence of obesity, its multifactorial nature, the complexity and lack of knowledge of the bodyweight control system, and the scarcity of adequate therapeutics have fuelled anti-obesity drug development during a considerable number of years. Irrespective of the efforts invested by researchers and companies, few products have reached a minimum level of effectiveness, and even fewer are available in medical practice. As a consequence of anti-obesity research, our knowledge of the bodyweight control system increased but, despite this, the pharmacological approaches to the treatment of obesity have not resulted yet in effective drugs. This review provides a panoramic of the multiple different approaches developed to obtain workable drugs. These approaches, however, rely in only four main lines of action: control of energy intake, mainly through modification of appetite;control of energy expenditure, essentially through the increase of thermogenesis;control of the availability of substrates to cells and tissues through hormonal and other metabolic factors controlling the fate of the available energy substrates; andcontrol of fat reserves through modulation of lipogenesis and lipolysis in white adipose tissue. A large prop...Continue Reading

References

Jun 28, 1979·Psychopharmacology·D C BalopoleD Dorph
Feb 1, 1979·The American Journal of Clinical Nutrition·J W Anderson, W J Chen
Nov 16, 1979·Science·W J FreedR J Wyatt
Aug 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R SamaninS Garattini
Sep 6, 1979·Nature·N J Rothwell, M J Stock
Apr 1, 1978·Pharmacology, Biochemistry, and Behavior·D LorenzG P Smith
Feb 1, 1976·British Journal of Clinical Pharmacology·J F GiudicelliA Berdeaux
Jun 1, 1977·Journal of Pharmaceutical Sciences·M HussainD M Long
Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Nov 1, 1976·European Journal of Pharmacology·M F SugrueS E Mireylees
Jan 1, 1975·Journal of Comparative and Physiological Psychology·G N Wade
Aug 1, 1975·The American Journal of Physiology·A S LuyckxP J Lefebvre
Jan 1, 1975·Nutrition and Metabolism·E Evans, D S Miller
Jan 1, 1992·Neuropharmacology·I S Ebenezer, A K Pringle
Jun 1, 1992·Drugs·T Silverstone
Aug 11, 1992·Pharmacology, Biochemistry, and Behavior·K E AsinA M Nadzan
Mar 1, 1992·Physiology & Behavior·J R JonesJ O Hill
Apr 1, 1992·The American Journal of Clinical Nutrition·S R SchwidR E Keesey
Feb 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·N SingewaldA Philippu
Jul 1, 1992·Metabolism: Clinical and Experimental·A AstrupF Quaade
Jan 1, 1992·The American Journal of Clinical Nutrition·S D Wise
Jan 11, 1992·The American Journal of Clinical Nutrition·J A NielsenL K Torgersen
Jan 1, 1992·The American Journal of Clinical Nutrition·T H MoranP R McHugh
Jan 1, 1992·The American Journal of Clinical Nutrition·T MatsuoH Ikeda
Jan 1, 1992·The American Journal of Clinical Nutrition·M Berger
Feb 1, 1992·The American Journal of Clinical Nutrition·G A Bray
Jul 1, 1991·Peptides·J E Morley, J F Flood
Oct 1, 1991·British Journal of Pharmacology·J GalitzkyM Berlan
Jan 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·M P Cleary
Jan 1, 1991·Physiology & Behavior·W LanghansE Scharrer
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·J R GlowaP W Gold

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Citations

Aug 12, 2006·Cyberpsychology & Behavior : the Impact of the Internet, Multimedia and Virtual Reality on Behavior and Society·Giuseppe RivaEnrico Molinari
Jan 2, 2013·International Journal of Health Care Quality Assurance·Sally Ezzat
Dec 24, 2008·Appetite·Valdo RiccaCarlo Faravelli
Mar 23, 2005·Journal of Molecular Graphics & Modelling·Hans De WinterMarijke Somers
May 3, 2005·European Journal of Pharmacology·Raquel Ferrer-LorenteMarià Alemany
Jun 9, 2005·Journal of the American Dietetic Association·Susan B Moyers
May 13, 2003·Expert Opinion on Pharmacotherapy·Paul Angulo
Jun 24, 2014·Journal of Ethnopharmacology·Carine Smith, Annadie Krygsman
May 18, 2005·Obesity Research·Aurélie BocquierAlain Paraponaris
Oct 3, 2014·Biological & Pharmaceutical Bulletin·Min Hye YangJinwoong Kim
Dec 9, 2004·Chemical Reviews·M N V Ravi KumarA J Domb

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