Pharmacological approaches to the treatment of residual symptoms

Journal of Psychopharmacology
Maurizio Fava

Abstract

Despite the efficacy of currently available antidepressant treatment, residual symptoms are common among individuals treated for major depressive disorder and are associated with an increased risk of relapse and poor psychosocial functioning. However, distinguishing treatment-emergent side effects from residual symptoms can be challenging for clinicians. Anxiety, sleep disturbance, somnolence/fatigue, apathy and cognitive dysfunction are among the more frequent residual symptoms. Approaches to the management of residual symptoms include addressing treatment-emergent side effects and co-morbid conditions, optimizing antidepressant dosing and using augmentation therapy. Clinicians are often guided in their decisions by anecdotal impressions. Studies assessing the evaluation and treatment of residual symptoms and side effects will contribute importantly to the optimal acute and long-term management of depression.

References

Oct 1, 1992·Archives of General Psychiatry·J MintzS S Hwang
Feb 1, 1990·Psychiatry Research·M E TancerR N Golden
Nov 1, 1983·Journal of Affective Disorders·A J RushD E Giles
Mar 1, 1995·Psychological Medicine·A F Tarbuck, E S Paykel
Jul 1, 1994·The American Journal of Psychiatry·A A NierenbergM Rosenthal
Nov 1, 1995·Psychological Medicine·E S PaykelA Barocka
Jun 1, 1996·The Psychiatric Clinics of North America·M Fava, K G Davidson
Jan 15, 1997·Psychiatry Research·A J Flint, S L Rifat
Aug 12, 1998·The American Journal of Psychiatry·O T DolbergL Grunhaus
Apr 30, 1999·The Journal of Clinical Psychiatry·A A NierenbergM Fava
Jul 13, 1999·The Journal of Clinical Psychiatry·J ZajeckaC M Beasley
Nov 5, 1999·The Journal of Clinical Psychiatry·G M AsnisJ K Walsh
Nov 26, 1999·The Journal of the American Dental Association·E S Brown, S C Hong
Sep 25, 2001·Depression and Anxiety·P D Nowell, D J Buysse
Jun 23, 2004·Journal of Affective Disorders·N Kennedy, E S Paykel
Sep 7, 2004·Journal of Clinical Psychopharmacology·George I PapakostasMaurizio Fava
Oct 14, 2004·Psychotherapy and Psychosomatics·Madelon Y Bolling, Robert J Kohlenberg
Oct 18, 2005·Bipolar Disorders·Keming Gao, Joseph R Calabrese

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Citations

Aug 1, 2008·Cognitive Therapy and Research·Neil P JonesMichael E Thase
Mar 10, 2012·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Louis S MatzaDennis A Revicki
Feb 25, 2011·Journal of Clinical Psychopharmacology·Shawn M McClintockAugustus John Rush
Mar 1, 2012·Environmental Health and Toxicology·Dongsoo Kim
Sep 14, 2007·Stress : the International Journal on the Biology of Stress·Irina Antonijevic
Nov 9, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kenn Freddy PedersenKolbjørn Brønnick
May 13, 2011·Journal of Affective Disorders·Scott PattenSerge Beaulieu
Apr 8, 2010·Human Psychopharmacology·Maria-Antonia Quera-SalvaChristian Guilleminault
Apr 8, 2010·Human Psychopharmacology·Ian Hindmarch, Kenji Hashimoto
Dec 5, 2009·Depression and Anxiety·Andrew W GoddardAnantha Shekhar
Aug 9, 2011·Journal of Affective Disorders·Louis S MatzaKaren G Malley
Jul 12, 2014·Journal of Affective Disorders·Genevieve S YuenGeorge S Alexopoulos
May 24, 2014·The International Journal of Neuropsychopharmacology·Ashley WallaceDavid A Morilak
Sep 28, 2014·European Archives of Psychiatry and Clinical Neuroscience·Rebecca SchennachHans-Jürgen Möller
Feb 27, 2016·Journal of Geriatric Psychiatry and Neurology·Isis Groeneweg-KoolhovenRoos C van der Mast
Oct 13, 2018·Psychological Medicine·Laura MandelliJoseph Zohar
Mar 20, 2010·CNS Drugs·Tracy L GreerMadhukar H Trivedi
Jan 2, 2013·Journal of Clinical Psychopharmacology·Mario VitaliMaurizio Fava

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