PMID: 2096103Jan 1, 1990Paper

Pharmacological aspects of chiral nonsteroidal anti-inflammatory drugs

Fundamental & Clinical Pharmacology
N MullerP Netter

Abstract

Most NSAIDs are chiral molecules: they exist under 2 configurations of non-superimposable mirror images which are termed enantiomers or optical isomers or optical antipodes. Direct or indirect (resolution) methods are used to separate this equal mixture of compounds. Some of the enantiomers of the NSAIDs are able to undergo chiral inversion from the inactive R(-) to the active S(+) form. The pharmacokinetics in terms of absorption, distribution, metabolism, protein binding and elimination may be different for the 2 enantiomers, leading to interindividual variability in clinical response and drug toxicity.

References

Mar 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D H Chatfield, J N Green
Oct 1, 1979·Journal of Pharmaceutical Sciences·J M KemmererB A Koechlin
Jan 1, 1979·Journal of Pharmaceutical Sciences·D M JohnsonG F Thompson
Apr 19, 1975·Biochimica Et Biophysica Acta·E C Ku, J M Wasvary
Oct 22, 1975·Journal of Chromatography·C H Lochmüller, R W Souter
Feb 1, 1976·Journal of Pharmaceutical Sciences·D G KaiserW J Wechter
Mar 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K J KripalaniE C Schreiber
Apr 1, 1989·Journal of Pharmaceutical Sciences·W F KeanH Howard-Lock
Jan 1, 1989·European Journal of Clinical Pharmacology·A M EvansA A Somogyi
Jun 1, 1989·Agents and Actions·G GeisslingerK Brune
May 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M MayerB Testa
Aug 1, 1988·Journal of Pharmaceutical Sciences·F JamaliA S Russell
Dec 1, 1988·British Journal of Clinical Pharmacology·B C SallustioP J Meffin
Jan 1, 1988·European Journal of Drug Metabolism and Pharmacokinetics·F Jamali
Jan 1, 1988·Journal of Pharmaceutical Sciences·R T FosterS R Alballa
May 1, 1986·Journal of Pharmaceutical Sciences·N N SinghK S Drader
Oct 1, 1986·Biochemical Pharmacology·K WilliamsA Duffield
Dec 1, 1986·Biochemical Pharmacology·S Fournel, J Caldwell
Jan 1, 1985·Journal of Pharmaceutical Sciences·A RubinR L Wolen
May 1, 1985·British Journal of Clinical Pharmacology·E J LeeD Champion
Nov 1, 1981·The Journal of Pharmacy and Pharmacology·S TamuraS Kishimoto
Sep 1, 1983·The Journal of Pharmacy and Pharmacology·A ButtinoniR Ceserani
Nov 1, 1983·The Journal of Pharmacy and Pharmacology·A J Hutt, J Caldwell
Mar 1, 1984·Journal of Biochemical and Biophysical Methods·S Allenmark
Nov 1, 1981·Journal of Pharmaceutical Sciences·J K StoltenborgF M Vane
Jan 1, 1980·European Journal of Drug Metabolism and Pharmacokinetics·R G SimmondsJ N Green

❮ Previous
Next ❯

Citations

Jun 1, 1996·Journal of Clinical Pharmacology·A CarabazaD Mauleón
Feb 14, 2006·Archives of Toxicology·Takashi NakazawaMasaharu Yamamoto
Dec 1, 1994·Journal of Dentistry·E Urquhart
Jan 1, 1995·Fundamental & Clinical Pharmacology·B BannwarthJ Dehais
Apr 12, 2013·Mediators of Inflammation·Mau SinhaTej P Singh
Jul 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·M J ThomasonA W Lloyd
Dec 15, 2015·The Journal of Pharmacology and Experimental Therapeutics·Atsushi KawaseMasahiro Iwaki
Dec 19, 2006·International Journal of Pharmaceutics·Anita ReddyHongliang Cai
Nov 1, 1995·Biopharmaceutics & Drug Disposition·M TodJ L Garcia-Mace
May 23, 2001·Clinical Pharmacokinetics·M J BarbanojI Gich
Dec 1, 1998·Journal of Clinical Pharmacology·Manel J BarbanojDavid Mauleón
Feb 16, 2006·Analytical Chemistry·Harald KneippKatrin Kneipp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.