PMID: 9655637Jul 9, 1998Paper

Pharmacological aspects of mouse hind-paw oedema induced by Lachesis muta rhombeata venom

Toxicon : Official Journal of the International Society on Toxinology
R Soares de MouraL C de Carvalho

Abstract

Pharmacological aspects of mouse hind-paw oedema induced by subplantar injections of Lachesis muta rhombeata (LMR) venom were investigated. The oedema induced by subplantar injections of 10 to 50 ng/g of LMR venom is dose dependent, with onset, peak and duration at 30, 60 and 180 min, respectively. Subplantar injection of 30 ng/g of Bothrops jararaca (BJ) venom induced oedema that has the same intensity as 30 ng/g of LMR venom but lasts for more than 4 h suggesting different time course. Systemic effects or haemorrhage were not observed with doses less than 50 ng/g. Oedema is not due to the presence of oedematogenic amines since dialysis did not change the oedema induced by 30 ng/g of LMR venom. Part of the oedema induced by LMR venom is due to a thermolabile fraction since pre-heating the venom at 100 degrees C for 15 min induced a significant reduction (56.19 +/- 6.8%) of the oedematogenic activity. The oedema induced by LMR venom is possibly induced by release of a pharmacological active substance at the site of injection. Histamine, arachidonate metabolites, nitric oxide and serotonin may play important roles in the oedematogenic effect of LMR venom since pre-treatment of mice with pyrilamine, indomethacin, dexamethasone, L...Continue Reading

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Citations

May 15, 2002·Biochemical Pharmacology·André L FulyJorge A Guimarães
Oct 8, 2003·Toxicon : Official Journal of the International Society on Toxinology·Ana M BarbosaJosé C Cogo
Jul 10, 1999·Toxicon : Official Journal of the International Society on Toxinology·A RucavadoJ M Gutiérrez
Jan 9, 2007·Toxicon : Official Journal of the International Society on Toxinology·Daniela C S DamicoCarla B Collares-Buzato
Jun 26, 2012·Journal of Biochemical and Molecular Toxicology·Lucas Benício CamposJosé Elpidio Barbosa
Aug 20, 2014·BioMed Research International·Jeison Saturnino-OliveiraLucindo José Quintans Júnior
Nov 6, 2012·Journal of Ethnopharmacology·Marcelo Abrahão StrauchPaulo A Melo

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