Pharmacological assessment of the contribution of the arterial baroreflex to sympathetic discharge patterns in healthy humans

Journal of Neurophysiology
Jacqueline K LimbergJ Kevin Shoemaker

Abstract

To study how changes in baroreceptor afferent activity affect patterns of sympathetic neural activation, we manipulated arterial blood pressure with intravenous nitroprusside (NTP) and phenylephrine (PE) and measured action potential (AP) patterns with wavelet-based methodology. We hypothesized that 1) baroreflex unloading (NTP) would increase firing of low-threshold axons and recruitment of latent axons and 2) baroreflex loading (PE) would decrease firing of low-threshold axons. Heart rate (HR, ECG), arterial blood pressure (BP, brachial catheter), and muscle sympathetic nerve activity (MSNA, microneurography of peroneal nerve) were measured at baseline and during steady-state systemic, intravenous NTP (0.5-1.2 µg·kg-1·min-1, n = 13) or PE (0.2-1.0 µg·kg-1·min-1, n = 9) infusion. BP decreased and HR and integrated MSNA increased with NTP ( P < 0.01). AP incidence (326 ± 66 to 579 ± 129 APs/100 heartbeats) and AP content per integrated burst (8 ± 1 to 11 ± 2 APs/burst) increased with NTP ( P < 0.05). The firing probability of low-threshold axons increased with NTP, and recruitment of high-threshold axons was observed (22 ± 3 to 24 ± 3 max cluster number, 9 ± 1 to 11 ± 1 clusters/burst; P < 0.05). BP increased and HR and integra...Continue Reading

References

Oct 1, 1979·Physiological Reviews·A B VallboB G Wallin
Dec 1, 1987·Journal of the Autonomic Nervous System·J FagiusB G Wallin
Jun 1, 1985·Brain : a Journal of Neurology·J FagiusS Englesson
Sep 1, 1974·The Journal of Physiology·J H Coote, V H Macleod
May 1, 1965·Journal of Neurophysiology·E HennemanD O Carpenter
Dec 15, 1994·The Journal of Physiology·V G MacefieldA B Vallbo
May 18, 1999·The American Journal of Physiology·L RudasD L Eckberg
Mar 17, 2001·The Journal of Physiology·P KienbaumB G Wallin
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jian CuiCraig G Crandall
Mar 1, 2003·Acta Physiologica Scandinavica·V G Macefield, M Elam
Aug 10, 2007·Clinical Pharmacology and Therapeutics·B W WilkinsJ H Eisenach
Jul 16, 2010·Autonomic Neuroscience : Basic & Clinical·Craig D SteinbackJ Kevin Shoemaker
Sep 14, 2010·Journal of Neuroscience Methods·Aryan SalmanpourJ Kevin Shoemaker
Oct 13, 2010·The Journal of Physiology·Craig D SteinbackJ Kevin Shoemaker
Mar 25, 2011·Journal of Neurophysiology·Aryan SalmanpourJ Kevin Shoemaker
Apr 14, 2011·The Journal of Physiology·Elisabeth A LambertGavin W Lambert
Apr 26, 2011·Autonomic Neuroscience : Basic & Clinical·Timothy B Curry, Nisha Charkoudian
Jan 19, 2012·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Aryan SalmanpourJ Kevin Shoemaker
Mar 24, 2012·Journal of Neurophysiology·Aryan Salmanpour, J Kevin Shoemaker
May 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mark B BadrovJ Kevin Shoemaker
Aug 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Mark B BadrovJ Kevin Shoemaker
Oct 28, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mark B BadrovJ Kevin Shoemaker
Aug 25, 2017·Journal of Neurophysiology·Mark B BadrovJ Kevin Shoemaker

❮ Previous
Next ❯

Citations

Jul 29, 2018·The Journal of Physiology·Stephen A KlassenJ Kevin Shoemaker
Nov 6, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anthony V IncognitoPhilip J Millar
Dec 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jacqueline K LimbergJaume Padilla
Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anthony V IncognitoLauro C Vianna
Feb 25, 2020·The Journal of Physiology·Stephen A KlassenJ Kevin Shoemaker
Aug 8, 2019·Journal of Neurophysiology·Elizabeth P OttJacqueline K Limberg
Apr 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth P OttJacqueline K Limberg
Nov 18, 2020·Autonomic Neuroscience : Basic & Clinical·Stephen A Klassen, J Kevin Shoemaker

❮ Previous
Next ❯

Software Mentioned

SigmaPlot
Systat

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.