PMID: 7028803Jul 1, 1981Paper

Pharmacological challenges to the endogenous opioid system in affective illness

Journal of Clinical Psychopharmacology
M R Cohen, D Pickar

Abstract

The discovery of an endogenous opioid system has been rapidly followed by animal studies suggesting its importance in neuroendocrine regulation and behavior. Abnormalities of these functions in affective illness suggest that evaluation of behavioral and hormonal responses following the clinical administration of opiate agonists or antagonists might yield information pertinent to the pathogenesis, diagnosis, and treatment of depression. However, initial double-blind controlled clinical studies have yielded little evidence to support this suggested involvement of the opioid system in affective illness. Acute administration of opiate agonists has sometimes yielded a mild antidepressant response in depression, and naloxone has occasionally been reported beneficial in mania. There is, however, little to suggest that these responses are specific to affective illness. A decreased prolactin response to morphine administration has been reported in depression, but is not direct evidence of opioid system dysfunction in depression since abnormal prolactin responses to other challenges in depression have previously been reported. The endogenous opioid system is actually multiple systems marked by distinct distributions of multiple endogenou...Continue Reading

Citations

Feb 1, 1983·Psychiatry Research·R M CohenD L Murphy
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·P N TariotR M Cohen
Feb 2, 2006·PLoS Medicine·Jodie A TraftonKeith Humphreys
Jan 1, 1982·Annals of the New York Academy of Sciences·D PickarW E Bunney
Jul 19, 2017·Anesthesia and Analgesia·Dermot P Maher, Steven P Cohen
Jul 1, 1984·Drug Intelligence & Clinical Pharmacy·M W JannS R Saklad

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