Pharmacological characterization of alpha 1-adrenoceptor subtype mediating regulation of arterial pressure and urethral perfusion pressure in the anaesthetized rat

Journal of Autonomic Pharmacology
C GuilmardP E Chabrier

Abstract

1. The alpha 1-adrenoceptor subtypes mediating the regulation of arterial pressure (AP) and urethral perfusion pressure (UP) in the anaesthetized rat were characterized by using selective alpha 1-adrenoceptor agonists and antagonists. 2. Intravenous administration of selective alpha 1-adrenoceptor agonists elicited a dose-dependent increase in AP and UP. The rank order of agonist potency: oxymetazoline (ED50, 6.2 and 8.2 nmol kg-1 > phenylephrine (ED50, 32 and 27 nmol kg-1 > methoxamine (ED50, 300 and 296 nmol kg-1 was the same for AP and UP, respectively. 3. The effects of phenylephrine on AP and UP were antagonized, in a dose related-manner, by pretreatment with alfuzosin, BMY 7378, 5-methyl-urapidil, phentolamine, prazosin, spiperone and WB 4101.5-methyl-urapidil was the only alpha 1-adrenoceptor antagonist more potent on UP than on AP. 4. The potency of the different alpha 1-adrenoceptor antagonists tested on AP and UP was significantly correlated with their binding affinity for the expressed recombinant alpha 1a-, but not alpha 1b- or alpha 1d-, adrenoceptor subtype. 5. The results suggest that in the anaesthetized rat (1) both AP and UP are regulated by the alpha 1A-adrenoceptor subtype; and (2) the urogenital selectivity...Continue Reading

References

Jan 16, 1995·European Journal of Pharmacology·A S GoetzD L Saussy
Dec 1, 1994·Journal of Autonomic Pharmacology·R Chess-WilliamsC Couldwell
Oct 1, 1993·The Journal of Pharmacy and Pharmacology·C CouldwellR Chess-Williams
Jun 30, 1994·Biochemical and Biophysical Research Communications·D H WeinbergM Bayne
Jul 1, 1993·Japanese Journal of Pharmacology·H Yazawa, K Honda
Dec 12, 1995·European Journal of Pharmacology·M AuguetP E Chabrier

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Citations

May 16, 2002·Experimental Neurology·Mitsuharu Yoshiyama, William C de Groat
Apr 1, 1997·Expert Opinion on Investigational Drugs·J P Hieble, R R Ruffolo
Feb 9, 2006·British Journal of Pharmacology·Martin C Michel, Wim Vrydag

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