Pharmacological characterization of the discriminative stimulus of inhaled 1,1,1-trichloroethane.

The Journal of Pharmacology and Experimental Therapeutics
Keith L Shelton

Abstract

The present study examined the involvement of the GABAA, N-methyl-D-aspartate (NMDA), nicotinic acetylcholine, and mu-opioid receptor systems in the transduction of the discriminative stimulus effects of the abused inhalant 1,1,1-trichloroethane (TCE). Sixteen B6SJLF1/J mice were trained to discriminate 10 min of exposure to 12,000-ppm inhaled TCE vapor from air. Substitution and antagonism tests and TCE blood concentration analysis were subsequently conducted. TCE blood concentrations decreased rapidly after cessation of exposure, falling by 66% within 5 min. TCE vapor concentration-dependently substituted for the 12,000-ppm training stimulus. The volatile anesthetic halothane concentration-dependently and fully substituted for TCE. The benzodiazepine midazolam partially substituted for TCE, producing a maximum of 68% TCE-lever selection. The benzodiazepine antagonist flumazenil attenuated midazolam substitution for TCE, but not the discriminative stimulus effects of TCE itself. The noncompetitive NDMA receptor antagonists phencyclidine and dizocilpine failed to substitute for TCE. Nicotine and the central nicotinic receptor antagonist mecamylamine also failed to produce any TCE-lever selection, nor did they antagonize the dis...Continue Reading

References

Jul 19, 1978·Psychopharmacology·T U Järbe, C Rollenhagen
Nov 10, 1976·Psychopharmacology·H E Shannon, S G Holtzman
Mar 1, 1990·Neurotoxicology and Teratology·J S KniselyR L Balster
Jan 1, 1996·Neurotoxicology and Teratology·S E Bowen, R L Balster
May 1, 1997·Pharmacology, Biochemistry, and Behavior·S E Bowen, R L Balster
Sep 2, 1998·Experimental and Clinical Psychopharmacology·S E Bowen, R L Balster
Feb 26, 1999·Experimental and Clinical Psychopharmacology·S E BowenR L Balster
May 26, 1999·Pharmacology, Biochemistry, and Behavior·S A VarvelL D Karan
Dec 31, 2002·Anesthesia and Analgesia·Erin M RadaPamela Flood
Sep 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·Cecilia M BorgheseR Adron Harris
Oct 27, 2004·Pharmacology, Biochemistry, and Behavior·Keith L Shelton, Robert L Balster
May 12, 2005·Toxicology and Applied Pharmacology·Ambuja S BaleTimothy J Shafer
Aug 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Timothy J ShaferJohn J Woodward
Sep 22, 2005·The Journal of Pharmacology and Experimental Therapeutics·Robert I Westphalen, Hugh C Hemmings
Oct 27, 2006·Neurotoxicology and Teratology·Scott E BowenSilvia L Cruz
Apr 12, 2007·Behavioural Pharmacology·Keith L Shelton
Nov 11, 2008·Annals of the New York Academy of Sciences·N Páez-MartínezS L Cruz
Feb 14, 2009·Addiction·Robert L BalsterLinda B Cottler
Mar 10, 2009·Pharmacology, Biochemistry, and Behavior·Keith L Shelton, Galina Slavova-Hernandez

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Citations

Jan 18, 2014·European Journal of Pharmacology·Keith L Shelton, Katherine L Nicholson
Aug 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob T Beckley, John J Woodward
Sep 17, 2011·Behavioural Pharmacology·Michael B Gatch, Michael J Forster
Sep 10, 2014·Journal of Drug and Alcohol Research·Keith L Shelton, Katherine L Nicholson
Sep 20, 2011·Drug and Alcohol Dependence·Keith L Shelton, Katherine L Nicholson
Dec 29, 2013·Behavioural Pharmacology·Kellianne J Richardson, Keith L Shelton

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