Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum

British Journal of Pharmacology
G M Drew

Abstract

1 The presynaptic alpha-adrenoceptors located on the terminals of the cholinergic nerves of the guineapig myenteric plexus have been characterized according to their sensitivities to alpha-adrenoceptor agonists and antagonists.2 Electrical stimulation of the cholinergic nerves supplying the longitudinal muscle of the guinea-pig ileum caused a twitch response. Clonidine caused a concentration-dependent inhibition of the twitch response; the maximum inhibition obtained was 80 to 95% of the twitch response. Oxymetazoline and xylazine were qualitatively similar to clonidine but were about 5 times less potent. Phenylephrine and methoxamine also inhibited the twitch response but were at least 10,000 times less potent than clonidine.3 The twitch-inhibitory effects of clonidine, oxymetazoline and xylazine, but not those of phenylephrine or methoxamine, were reversed by piperoxan (0.3 to 1.0 mug/ml).4 Lysergic acid diethylamide (LSD) inhibited the twitch response, but also increased the basal tone of the ileum. Mepyramine prevented the increase in tone but did not affect the inhibitory action of LSD. Piperoxan or phentolamine only partially antagonized the inhibitory effect of LSD.5 Phentolamine, yohimbine, piperoxan and tolazoline were...Continue Reading

References

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
Apr 1, 1977·British Journal of Pharmacology·A G Blakeley, R J Summers
Apr 1, 1975·The Journal of Physiology·N AmbacheM A Zar
Mar 1, 1976·British Journal of Pharmacology·A A Anderson, G M Lees
Dec 1, 1965·British Journal of Pharmacology and Chemotherapy·D A Brown, J P Quilliam
Jun 1, 1967·British Journal of Pharmacology and Chemotherapy·M Dzoljić
Jun 1, 1968·European Journal of Pharmacology·C Raper, J Wale
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke
Jul 1, 1974·Biochemical Pharmacology·S Z Langer
Dec 1, 1973·British Journal of Pharmacology·J Hughes
Jun 1, 1968·British Journal of Pharmacology and Chemotherapy·H W Kosterlitz, A J Watt
Sep 1, 1955·British Journal of Pharmacology and Chemotherapy·G W CAMBRIDGE, J A HOLGATE
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jun 1, 1963·British Journal of Pharmacology and Chemotherapy·J HARRY
Dec 1, 1960·British Journal of Pharmacology and Chemotherapy·H BoydM J Rand
Dec 1, 1974·British Journal of Clinical Pharmacology·D A RichardsJ G Maconochie

Citations

May 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·C A Taira, M A Enero
Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H KilbingerI Wessler
Oct 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·M AndréjakH Schmitt
Sep 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R E Loiacono, D F Story
Apr 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·R A LefebvreM G Bogaert
Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·I Pfeuffer-Friederich, H Kilbinger
Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·K J Broadley, P F Grassby
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·Y PommierH Schmitt
Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·R R RuffoloJ S Horng
Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·T Tanaka, K Starke
Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·H Kilbinger, I Wessler
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R A BondD E Clarke
Dec 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·B CostallC C Tan
May 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·R A LefebvreM G Bogaert
Dec 1, 1979·Irish Journal of Medical Science·G A FitzGerald
Jul 10, 1981·European Journal of Pharmacology·T D Johnson, D E Clarke
Sep 10, 1982·European Journal of Pharmacology·W H Hsu
Jul 15, 1983·European Journal of Pharmacology·C B ChapleoN K Virdee
Dec 17, 1985·European Journal of Pharmacology·M L Vargas, A J Brugger
Dec 1, 1987·European Journal of Pharmacology·L BrasiliW Quaglia
Nov 10, 1987·European Journal of Pharmacology·D L DecktorM M Davis
Aug 21, 1990·European Journal of Pharmacology·R A LefebvreF A De Beurme
Jan 1, 1980·The International Journal of Biochemistry·E D SaggersonC A Carpenter
Nov 1, 1986·Pharmacology, Biochemistry, and Behavior·A G MolloyJ J Buccafusco
Jan 1, 1983·Pharmacology & Therapeutics·A J Scriven, P J Lewis
Jan 1, 1985·General Pharmacology·D R Mottram, P Saggar
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T KitazawaH Kondo
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T KitazawaH Kondo
May 20, 1998·Drug and Alcohol Dependence·A PinelliR Spezia
Oct 25, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A LuziM Palmery
Nov 1, 1996·Journal of Pharmacological and Toxicological Methods·I M Coupar, L Liu
Aug 21, 2003·Autonomic Neuroscience : Basic & Clinical·Teruyasu UmezawaTadashi Hisamitsu
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J Wiley, C Owyang
Aug 1, 1991·Journal of Autonomic Pharmacology·F GuenanecheR A Lefebvre
Oct 1, 1979·British Journal of Pharmacology·G M Drew, S B Whiting
Apr 1, 1991·British Journal of Pharmacology·C A HallidayM B Tyers
Apr 1, 1991·British Journal of Pharmacology·I AkersA T Sullivan
Feb 1, 1995·Acta Physiologica Scandinavica·N O Sjöstrand, M Hammarström
Aug 15, 1998·Equine Veterinary Journal·T J DohertyD L Frazier
May 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·M MarcoliG M Frigo
Aug 27, 2013·Experimental Physiology·Anastasia A BorodinovaGalina S Sukhova
Jul 1, 1987·British Journal of Pharmacology·R A Bond, D E Clarke
Jun 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·A NolanA Waterman
Dec 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·T Roger, Y Ruckebusch
Jun 1, 1985·British Journal of Pharmacology·H Kilbinger, I Pfeuffer-Friederich
Dec 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·S A Greene, J C Thurmon
Jun 1, 1985·British Journal of Pharmacology·L A Chahl
Sep 1, 1981·Journal of Veterinary Pharmacology and Therapeutics·W H HsuP Lee
Nov 1, 1985·Acta Physiologica Scandinavica·M Hammarström
Jul 7, 1980·Brain Research·A Leppävuori, P T Putkonen
Dec 3, 1985·European Journal of Pharmacology·E H OhlsteinB A Berkowitz
Aug 28, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christianna KreissAnthony J Bauer
Aug 1, 1989·Journal of Neurochemistry·C Gulat-MarnayJ Schwartz
Mar 1, 1981·Journal of Neurochemistry·C A Briggs, J R Cooper
Jun 1, 1985·Journal of Autonomic Pharmacology·J P HiebleO S Steinsland
Nov 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·A T Sullivan, G M Drew
Sep 24, 1999·Veterinary Surgery : VS·T J DohertyD L Frazier
Nov 1, 1984·Acta Pharmacologica Et Toxicologica·S SteenK E Andersson
Jan 1, 1984·British Journal of Pharmacology·A LivingstonB Morris
Mar 1, 1981·Journal of Autonomic Pharmacology·P B Timmermans, P A van Zwieten
Oct 1, 1980·British Journal of Pharmacology·R C Dage, C P Hsieh
Jun 1, 1981·The Journal of Pharmacy and Pharmacology·T NakakiR Kato
Oct 1, 1981·British Journal of Pharmacology·K Morita, R A North
Oct 3, 2001·Physiological Reviews·H E de Wardener
Jun 1, 1981·British Journal of Pharmacology·H O CollierD L Francis
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·K E Andersson
Oct 1, 1983·The Journal of Pharmacy and Pharmacology·D R Mottram
Sep 1, 1984·The Journal of Pharmacy and Pharmacology·P F Grassby, K J Broadley
May 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·R R RuffoloJ S Horng
Aug 1, 1984·The Journal of Pharmacy and Pharmacology·T TakenakaN Inukai

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