Pharmacological classes that extend lifespan of Caenorhabditis elegans

Frontiers in Genetics
Maria CarreteroMichael Petrascheck

Abstract

Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.

References

Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Dec 2, 1993·Nature·C KenyonR Tabtiang
Jun 6, 2000·Journal of Biomolecular Screening·J H ZhangK R Oldenburg
Oct 5, 2001·Trends in Genetics : TIG·M Robinson-RechaviV Laudet
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hyung-Lyun KangKyung-Tai Min
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James J Moresco, Michael R Koelle
Jan 18, 2005·Science·Kimberley EvasonKerry Kornfeld
Jan 31, 2006·Aging Cell·Mark A WilsonCatherine A Wolkow
Jul 15, 2006·Nature Biotechnology·Gaia V PaoliniAndrew L Hopkins
Jul 29, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tamas Bartfai
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Apr 7, 2007·PLoS Genetics·Sean P Curran, Gary Ruvkun
Oct 9, 2007·Nature Biotechnology·Muhammed A YildirimMarc Vidal
Oct 26, 2007·The Journal of Biological Chemistry·Gawain McCollGordon J Lithgow
Nov 13, 2007·Aging Cell·Srinivas AyyadevaraRobert J Shmookler Reis
Nov 23, 2007·Nature·Michael PetrascheckLinda B Buck
Aug 30, 2008·Experimental Gerontology·Michael G BenedettiGordon J Lithgow
Feb 7, 2009·PLoS Genetics·Jeremy M Van Raamsdonk, Siegfried Hekimi
Jul 10, 2009·Nature·David E HarrisonRichard A Miller
Jun 29, 2010·Current Topics in Microbiology and Immunology·Peter K VogtAdam Denley
Nov 10, 2010·Nucleic Acids Research·Craig KnoxDavid S Wishart
Nov 19, 2010·Nature·Eranthie WeerapanaBenjamin F Cravatt
Apr 13, 2011·Aging·Alexey Moskalev, Mikhail Shaposhnikov
Nov 8, 2011·Nature Chemical Biology·Genna M LucianiPeter J Roy
Jan 14, 2012·Journal of the American Chemical Society·Stephan H von ReussFrank C Schroeder
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andreas H LudewigFrank C Schroeder
Aug 1, 2013·Nature Communications·Alejandro Martin-MontalvoRafael de Cabo
Oct 19, 2013·Aging Cell·Xiaolan YeMichael Petrascheck

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Citations

May 26, 2016·Aging Cell·Mark LucanicGordon J Lithgow
May 10, 2016·F1000Research·Simon Melov
Apr 16, 2016·F1000Research·Surinder Kumar, David B Lombard
Jun 6, 2017·Aging and Disease·Alexey MoskalevMikhail Shaposhnikov
Jun 13, 2019·Biogerontology·Darío R Gómez-LintonLaura J Pérez-Flores
May 25, 2016·Molecular Psychiatry·S RangarajuA B Niculescu
Jun 21, 2020·Biogerontology·Georges E Janssens, Riekelt H Houtkooper
Aug 8, 2017·Aging·Diogo G BarardoAlex A Freitas

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