Pharmacological determinants of the reinforcing effects of psychostimulants: relation to agonist substitution treatment

Experimental and Clinical Psychopharmacology
Joshua A Lile

Abstract

Illicit use of psychostimulants, such as cocaine and methamphetamine, continues to pose a significant public health concern. On the basis of the relative success at treating opiate and tobacco users with agonist substitution treatments, this strategy has been pursued in the search for a pharmacotherapy for psychostimulant addiction. The reinforcing effects of drugs are central to their abuse liability; therefore, gaining a better understanding of the factors that determine the reinforcing effects of psychostimulants should inform the development of an effective treatment. Although the reinforcing effects of drugs are known to be multiply determined, the author's dissertation research focused on pharmacological factors. This review presents results from that research as well as findings reported in the extant literature, suggesting that the reinforcing effects of psychostimulant drugs are determined both by their pharmacodynamic and pharmacokinetic profiles. There is evidence to support the conclusion that affinity for dopamine transporters appears to be of critical importance, whereas serotonin transporters seem to serve a modulatory function. A more rapid rate of onset may enhance a drug's reinforcing effects, but a drug with ...Continue Reading

References

Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·C E JohansonK Bonese
Feb 1, 1976·Pharmacology, Biochemistry, and Behavior·M C Wilson, C R Schuster
Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·C E LauG R King
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·K E VanoverW L Woolverton
Oct 1, 1991·Drug and Alcohol Dependence·L H Gold, R L Balster
Jun 1, 1990·The American Journal of Medicine·C Wright, R D Moore
Nov 1, 1990·Computer Methods and Programs in Biomedicine·J M Pallo
Apr 27, 1988·European Journal of Pharmacology·G BattagliaE B De Souza
Feb 1, 1985·Drug and Alcohol Dependence·R L Balster, S E Lukas
Jul 1, 1973·Journal of the Experimental Analysis of Behavior·R L Balster, C R Schuster
Jan 1, 1981·Psychopharmacology·M E Risner, D L Silcox
Jun 1, 1995·Psychopharmacology·M StathisM J Kuhar
Jan 1, 1995·Accident and Emergency Nursing·B Wright
Jun 1, 1994·Psychopharmacology·M A Nader, D M Reboussin
Jun 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N K Mello, S S Negus
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·M J Kreek
Aug 6, 1999·Psychopharmacology·D C RobertsH Davies
Aug 7, 1999·Primary Care·R V FantJ E Henningfield

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Citations

Oct 5, 2007·Current Psychiatry Reports·David R Janero, Alexandros Makriyannis
Dec 18, 2008·Experimental and Clinical Psychopharmacology·Richard B RothmanMichael H Baumann
Oct 4, 2011·The Journal of Pharmacology and Experimental Therapeutics·Brett C GinsburgLance R McMahon
Jun 30, 2009·Psychiatry Research·Bryon AdinoffMark J Williams
Nov 18, 2008·Drug and Alcohol Dependence·Carmela M ReichelRick A Bevins
Feb 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·James J MahoneyThomas F Newton
Jan 30, 2007·Pharmacology, Biochemistry, and Behavior·Heather L KimmelLeonard L Howell
Nov 11, 2008·Annals of the New York Academy of Sciences·Megan P H Osborne, M Foster Olive
Jul 20, 2010·European Journal of Pharmacology·William W StoopsCraig R Rush
Nov 3, 2010·Neuroscience and Biobehavioral Reviews·Eoin C O'ConnorAndy N Mead
Jan 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Stevens Negus, Jack Henningfield
Apr 27, 2016·Drug and Alcohol Dependence·Stephanie Collins Reed, Suzette M Evans
Sep 6, 2008·Progress in Brain Research·Richard B RothmanMichael H Baumann
Nov 27, 2009·Journal of Psychopharmacology·Dinkar Sharma, Sharon Money
Feb 9, 2011·The Journal of Pharmacology and Experimental Therapeutics·John A GrunerMaciej Gasior
Jul 19, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Florence AllainAnne-Noël Samaha
Aug 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily M Black, Rodrigo A España
Mar 28, 2008·Drug and Alcohol Review·James Shearer
Dec 9, 2020·Drug and Alcohol Dependence·Craig R RushAbner O Rayapati

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