PMID: 6168890Jan 1, 1981Paper

Pharmacological effect of beta toxin of Clostridium perfringens type C on rats

Microbiology and Immunology
J SakuraiK Endo

Abstract

The biological effect of purified beta toxin of Clostridium perfringens type C in vivo was investigated. After intravenous injection of the purified beta toxin into rats, a rise in blood pressure and a simultaneous fall in heart rate were observed. After the blood pressure reached a maximum, the heart rate recovered gradually, and electrocardiographic and respiratory changes began. The rise in blood pressure induced by beta toxin tended to be proportional to the amount of toxin. The latent period between the injection of toxin and the onset of the increase, and also the time between the injection and the maximum pressure induced by the toxin decreased with increasing concentration of the toxin. A good correlation was found between the factor producing the rise in blood pressure and beta toxin. Alpha adrenergic and ganglionic blocking agents reduced blood pressure levels elevated by beta toxin. The data suggest that the toxin causes a release of catecholamines, and that the increase in blood pressure was induced by released catecholamines.

References

Dec 1, 1977·Infection and Immunity·J Sakurai, C L Duncan
Aug 1, 1978·Infection and Immunity·J Sakurai, C L Duncan
Sep 1, 1966·The Journal of Hygiene·T G MurrellP D Walker
Mar 1, 1959·The Journal of Hygiene·H I FIELD, R F GOODWIN
Feb 12, 1949·British Medical Journal·J ZEISSLER, L RASSFELD-STERNBERG
Jan 22, 1949·Lancet·H BARCROFT, H KONZETT

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Citations

Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·J SakuraiY Fujii
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·J Sakurai, Y Fujii
Mar 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·J SakuraiM Nagahama
Jan 11, 2003·British Journal of Pharmacology·Masahiro NagahamaJun Sakurai
Feb 6, 2015·Toxins·Masahiro NagahamaKeiko Kobayashi
Jan 1, 1984·Microbiology and Immunology·J SakuraiK Endo
Aug 25, 2015·Biochimica Et Biophysica Acta·Masahiro NagahamaJun Sakurai
Jul 24, 2013·Infection and Immunity·Masahiro NagahamaJun Sakurai
May 24, 2013·Microbiology and Molecular Biology Reviews : MMBR·Ferdinand C O LosAdam J Ratner
Dec 19, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J LiuR Li
Jan 1, 1990·Clinical Microbiology Reviews·C L Hatheway

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