PMID: 11931077Apr 5, 2002Paper

Pharmacological effects of latanoprost, prostaglandin E2, and F2alpha on isolated rabbit ciliary artery

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Hitoshi IshikawaKimiya Shimizu

Abstract

Latanoprost is a prostaglandin (PG)F2alpha analogue widely recognized in the treatment of glaucoma. To investigate the action of this drug on the ocular circulation, we have studied its effects on isolated rabbit ciliary artery. The data obtained on this drug are compared with the data from PGE2 and PGF2alpha. Under the microscope, ciliary artery specimens were prepared from rabbit eyes and mounted in a myograph system. The effects of latanoprost, PGE2, and PGF2alpha on the isolated rabbit ciliary artery were investigated in vitro using isometric tension recording methods. Exogenously applied PGF2alpha, but not latanoprost, evoked contraction in the rabbit ciliary artery. After precontraction with excess-[K]0 solution, latanoprost evoked relaxation dose-dependently. Latanoprost at a concentration of 100 microM induced maximum relaxation, which was not blocked by 10 microM L-nitro-L-arginine methylester (L-NAME), 1 microM 8-37 calcitonin gene-related peptide (CGRP) or 10 microM indomethacin. Moreover, latanoprost induced relaxation even in preparations without endothelium. The maximum relaxation obtained with PGE2 was somewhat less than 50% of that with latanoprost. These results indicate that latanoprost and PGE2 relaxed rabbit...Continue Reading

Citations

Jun 15, 2011·Japanese Journal of Ophthalmology·Hiroshi WatabeTakeshi Yoshitomi
Jan 17, 2013·Japanese Journal of Ophthalmology·Chihiro Mayama, Makoto Araie
Nov 29, 2013·Expert Opinion on Therapeutic Patents·Yangbo Feng, Philip V LoGrasso
Apr 27, 2007·Experimental Eye Research·Yaru DongTakeshi Yoshitomi
Dec 21, 2006·Japanese Journal of Ophthalmology·Yaru DongTakeshi Yoshitomi
Apr 17, 2003·Current Opinion in Ophthalmology·Camille Hylton, Alan L Robin
Aug 7, 2012·Acta Ophthalmologica·Sidse KringelholtToke Bek

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