Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review

Fundamental & Clinical Pharmacology
Amaurilio O NogueiraGislei Frota Aragão

Abstract

Protium heptaphyllum Aubl. belongs to the Burseraceae family. It is commonly called 'almecegueira' and is known to produce an amorphous resin which has constituents such as α- and β-amyrin, taraxastan-3-oxo-20-ol and sitostenonein. The α- and β-amyrin from P. heptaphyllum have pharmacological activities in several systems, such as central and peripheral nervous system, gastrointestinal tract and immunological system. In this study, our objective was to review pharmacological activities and to gather more information on the mixture of α- and β-amyrin obtained from P. heptaphyllum to guide future preclinical and clinical studies using this compound. This review consisted of searches performed using scientific databases such as PubMed, SciELO, LILACS, SciFinder and Science Direct. Some uses of α- and β-amyrin have been partially confirmed by previous studies demonstrating analgesic, anti-inflammatory, anticonvulsant, antidepressive, gastroprotective, hepatoprotective, antipancreatitic, anticholytic, antihyperglycemic and hypolipidemic effects. It is noteworthy that there are no α- and β-amirin toxicity tests described in the literature as recommended in the international guidelines, and such tests are one of the research stages to...Continue Reading

References

Jul 11, 2000·Natural Product Reports·D J NewmanK M Snader
Sep 7, 2001·Fitoterapia·G S SusunagaF Delle Monache
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Francisco A OliveiraVietla S N Rao
Dec 1, 2007·Journal of Nanoscience and Nanotechnology·Hyung Seok KangGiyoong Tae
Jan 1, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S A Holanda PintoV S Rao
Feb 21, 2008·Journal of Herbal Pharmacotherapy·Gislei Frota AragãoGlauce S de Barros Viana
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 8, 2010·World Journal of Gastroenterology : WJG·Caroline-Mourão MeloMariana-Helena Chaves
Mar 15, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Caroline M MeloFlávia A Santos
Aug 8, 2012·Lipids in Health and Disease·Flávia Almeida SantosVietla Satyanarayana Rao
Oct 30, 2013·Current Medicinal Chemistry·F CiccarelliL Ginaldi
Jan 27, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafael C DutraJoão B Calixto
Jul 15, 2016·Fundamental & Clinical Pharmacology·Rafia A BhatSurendra K Tandan
Dec 3, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Pankaj PrabhakarYogendra Kumar Gupta
Feb 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ritu KhanraNiloy Bhattacharjee
Mar 10, 2017·Free Radical Research·Alaa RefaatHelen R Griffiths
Jan 6, 2018·Thrombosis and Haemostasis·Aldo BonaventuraFranco Dallegri

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Citations

Aug 4, 2020·Parasitology·Célia Eliane de Lara da SilvaMaria Valdrinez Campana Lonardoni
Nov 30, 2019·TheScientificWorldJournal·Josiane Lima MendesRenata Albuquerque Costa
Apr 4, 2021·International Journal of Molecular Sciences·Giuseppe ManninoCarla Gentile
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alberto AsteggianoClaudio Medana
Jun 29, 2021·Journal of Diabetes and Metabolic Disorders·Regina Ngozi UgbajaOluseyi Adeboye Akinloye
Feb 18, 2021·Canadian Journal of Physiology and Pharmacology·Abraham Giacoman-MartínezJulio César Almanza-Pérez
Sep 17, 2021·Journal of Biomolecular Structure & Dynamics·Raissa C OliveiraAlexandre M R Teixeira

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