Pharmacological enhancement of neuronal survival

Critical Reviews in Toxicology
Edward J Calabrese

Abstract

This article is a comprehensive assessment of the quantitative features of the dose response for neuroprotective agents and their underlying mechanistic foundations. The data were derived from published studies using numerous primary neuronal cell cultures and neuronal cell lines. These biological models assessed normal developmental and aging processes, preconditioning adaptive responses, and various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. The nature of the dose response was generally U-shaped with quantitative features similar to the hormetic dose-response model and independent of biological model, endpoint measured, and chemical class. The agents displaying the U-shaped dose response for neuronal survival include numerous endogenous agonists, plant-derived agents, synthetic drugs, and widely used chemicals including potent neurotoxins. That neuroprotective agents display similar dose-response relationships regardless of experimental system, potency, and endpoint is an important observation with widespread biomedical and clinical implications.

References

Apr 15, 1975·The Journal of Comparative Neurology·V Hamburger
Nov 1, 1975·Neuropharmacology·B CostallC Pycock
May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Jan 1, 1990·Brain Research. Developmental Brain Research·D E BrennemanP G Nelson
Jun 1, 1990·Journal of Medicinal Chemistry·R L JohnsonR K Mishra
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D E BrennemanP G Nelson
Jul 1, 1990·Journal of Neurochemistry·T Shimizu, L S Wolfe
Jan 1, 1989·European Journal of Clinical Pharmacology·Y HirataM Ishii
Jan 1, 1989·Annals of the New York Academy of Sciences·N G Bazan
Jan 1, 1989·International Review of Neurobiology·C J Frederickson
Jan 1, 1989·Annals of the New York Academy of Sciences·C Y HsuB A Freeman
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·C Hara, A J Kastin
Mar 1, 1986·The Biochemical Journal·A E Pegg
Jan 1, 1987·Developmental Neuroscience·C AruffoJ Cérvos-Navarro
Jul 1, 1988·Journal of Medicinal Chemistry·K L YuR L Johnson
Jan 1, 1987·Progress in Brain Research·P Brundin, A Björklund
Feb 1, 1987·Journal of Neurochemistry·K AbeK Miyamoto
May 17, 1974·Nature·D SchubertB L Brandt
Nov 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·N P PlotnikoffA V Schally
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt

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Citations

Apr 4, 2013·Antioxidants & Redox Signaling·Carolin CorneliusSalvatore Cuzzocrea
Oct 10, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeferson L FrancoPeter R Dunkley
Apr 13, 2011·Journal of Cell Communication and Signaling·Edward J Calabrese, Mark P Mattson
May 19, 2009·BioFactors·Vittorio CalabreseEdward J Calabrese
Oct 25, 2011·Molecular Aspects of Medicine·Vittorio CalabreseEdward J Calabrese
Nov 20, 2016·Journal of Neuroscience Research·Manuela PennisiVittorio Calabrese
Mar 25, 2010·Human & Experimental Toxicology·Edward J Calabrese
Dec 1, 2010·Human & Experimental Toxicology·Edward J CalabreseVittorio Calabrese
May 5, 2009·Human & Experimental Toxicology·Ej Calabrese
Mar 25, 2014·Dose-response : a Publication of International Hormesis Society·Rehana K Leak
Apr 25, 2008·Critical Reviews in Toxicology·Edward J Calabrese
Jun 24, 2008·Critical Reviews in Toxicology·Edward J Calabrese
Jan 25, 2012·Biogerontology·Edward J CalabreseVittorio Calabrese
Aug 24, 2019·Addiction Biology·João AlexandreJoão Pedro Silva
Oct 19, 2016·Journal of Neuroscience Research·Vittorio CalabreseEdward J Calabrese
Oct 19, 2016·Journal of Neuroscience Research·V CalabreseE J Calabrese
Nov 9, 2010·Human & Experimental Toxicology·Lucija SarcMetoda Lipnik-Stangelj
Oct 13, 2012·Human & Experimental Toxicology·E J CalabreseV Calabrese
Jul 25, 2019·Brain Circulation·Joseph DeFrancoJames Giordano
Oct 8, 2009·Dose-response : a Publication of International Hormesis Society·A R D Stebbing
Nov 22, 2016·Dose-response : a Publication of International Hormesis Society·B A KatsnelsonM P Sutunkova
Aug 12, 2018·Journal of Neuroscience Research·Vittorio CalabreseEdward J Calabrese
Jan 23, 2020·ACS Chemical Biology·Casey J AdamsThomas J Meade
Oct 18, 2018·European Journal of Pharmacology·Farshad Homayouni MoghadamMohammad Hossein Nasr-Esfahani
Jul 24, 2021·IUBMB Life·Edward J Calabrese, Evgenios Agathokleous
Jan 1, 2017·Brain Circulation·Edward J CalabreseJames Giordano

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