Pharmacological evidence for activation of phospholipid and small GTP binding protein signalling cascades by Nod factors

Plant Physiology and Biochemistry : PPB
M N Kelly-Skupek, Helen R Irving

Abstract

The effects of lipo-chitin oligosaccharide Nod factors (NodNGR[S] from Rhizobium sp. NGR234) on root hair deformation in Vigna unguiculata (L.) Walp. were studied using pharmacological agents to mimic and/or inhibit their action. It was hypothesised that the rearrangement of the cytoskeleton seen during Nod factor induced root hair deformation is modulated by protein kinase C, monomeric G proteins of the Rho superfamily and the location and amount of phosphatidylinositol 3-phosphates (PI3Ps). This hypothesis is supported by the following observations. The protein kinase C activators, 12-deoxyphorbol 13-acetate (DPA) and diacylglycerol kinase inhibitor 1, stimulated root hair deformation to a level similar to that seen with Nod factors or mastoparan, whereas the inhibitor Gö 6976 inhibited root hair deformations induced by NodNGR[S], mastoparan, DPA and diacylglycerol kinase inhibitor 1. The Ras antagonists mevastatin and sulindac sulphide, and the Rho antagonist exoenzyme C3 toxin from Clostridium botulinum all inhibited Nod factor stimulated root hair deformation. Pasteurella multocida toxin activates Rho and stimulated root hair deformation, this stimulation was inhibited by both neomycin and exoenzyme C3 toxin. The PI3 kinas...Continue Reading

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Citations

May 6, 2011·Molecular Plant-microbe Interactions : MPMI·Jeremy D Murray
Aug 13, 2009·PloS One·Tita RitsemaMaikel P Peppelenbosch
Jul 1, 2007·Plant Signaling & Behavior·Catalina I Pislariu, Rebecca Dickstein

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