PMID: 7540290Jan 1, 1995Paper

Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells

Peptides
S FukuharaE Munekata

Abstract

We found that neurokinin A (NKA) and neurokinin B (NKB) induce an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) in murine neuroblastoma C1300 cells (EC50: NKA 87 +/- 13 nM, NKB 97 +/- 15 nM). Substance P (SP) also caused a transient Ca2+ increase, although the potency of SP was much less than that of NKA and NKB. The increase in [Ca2+]i induced by NKA and NKB was inhibited by SR 48,968, a selective antagonist for NK2, and [beta Ala8]NKA(4-10), a selective agonist for NK2, did not stimulate the increase in [Ca2+]i. NKA- and NKB-induced Ca2+ mobilization was not inhibited by CP-96,345 and [Trp7, beta Ala8]NKA(4-10), selective antagonists for NK1 and NK3, respectively. These results suggested that C1300 cells express endogenous NK2 neurokinin receptors that have different features from known NK2 receptors.

References

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Citations

Apr 12, 2001·Neuroscience Letters·M BensaidF Oury-Donat
Aug 19, 2007·Biochemical and Biophysical Research Communications·Hidehito MukaiEisuke Munekata
Dec 15, 2010·Biochemical and Biophysical Research Communications·Tetsuo SekiHidehito Mukai
Jul 29, 2008·Biochemical and Biophysical Research Communications·Hidehito MukaiEisuke Munekata
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hidehito MukaiEisuke Munekata

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