Pharmacological evidence for the activation of K(+) channels by diclofenac

European Journal of Pharmacology
Mario I OrtizVinicio Granados-Soto

Abstract

The involvement of K(+) channels in the antinociceptive action of diclofenac was assessed in the formalin test. Local administration of diclofenac produced a dose-dependent antinociceptive effect due to a local action because drug administration in the contralateral paw was ineffective. Pretreatment of the injured paw with glibenclamide and tolbutamide (ATP-sensitive K(+) channel inhibitors), charybdotoxin and apamin (large- and small-conductance Ca(2+)-activated K(+) channel blockers, respectively), 4-aminopyridine or tetraethylammonium (voltage-dependent K(+) channel inhibitors) prevented diclofenac-induced antinociception. Given alone, K(+) channel inhibitors did not modify formalin-induced nociceptive behavior. Pinacidil (an ATP-sensitive K(+) channel opener) also produced antinociception which was blocked by glibenclamide. The peripheral antinociceptive effect of morphine (positive control) was blocked by glibenclamide and 4-aminopyridine but not by charybdotoxin or apamin. The results suggest that the peripheral antinociceptive effect of diclofenac may result from the activation of several types of K(+) channels, which may cause hyperpolarization of peripheral terminals of primary afferents.

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Citations

Jul 19, 2012·Purinergic Signalling·Sérgio José Macedo-JuniorAdair Roberto Soares Santos
Jan 28, 2004·European Journal of Pharmacology·Teresa Mixcoatl-ZecuatlVinicio Granados-Soto
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Juan M Jiménez-AndradeGilberto Castañeda-Hernández
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Mario I OrtizGilberto Castañeda-Hernández
Sep 10, 2013·Life Sciences·Geovanna Nallely Quiñonez-BastidasVinicio Granados-Soto
Jun 8, 2013·Pharmacological Reports : PR·Jorge E Torres-LópezHéctor I Rocha-González
Feb 10, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·I I Acosta-MadridM I Ortiz
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Sep 5, 2012·The Journal of Pharmacy and Pharmacology·Asfree GwanyanyaKanigula Mubagwa
May 7, 2011·Journal of Clinical Pharmacy and Therapeutics·R B Raffa, J V Pergolizzi
Jun 30, 2006·Biochemical and Biophysical Research Communications·Xiao-Wei FeiYan-Ai Mei
Oct 7, 2004·European Journal of Pharmacology·María OcañaJosé Manuel Baeyens
Nov 8, 2003·Brain Research·Hyang Mi LeeJin Ho Song
May 18, 2004·European Journal of Pharmacology·Vinicio Granados-SotoFrancisco J Flores-Murrieta
Aug 11, 2006·Pharmacology, Biochemistry, and Behavior·Deysi Y Bermúdez-OcañaVinicio Granados-Soto
Jan 28, 2006·European Journal of Pharmacology·Teresa Mixcoatl-ZecuatlVinicio Granados-Soto
Jan 3, 2006·Pharmacology, Biochemistry, and Behavior·Mario I OrtizGilberto Castañeda-Hernández
Jun 29, 2005·Pharmacology, Biochemistry, and Behavior·Mario I OrtizVinicio Granados-Soto
May 10, 2005·European Journal of Pharmacology·Jair Lozano-CuencaVinicio Granados-Soto
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Apr 9, 2005·European Journal of Pharmacology·Daniela F Pacheco, Igor D G Duarte
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Jan 18, 2008·Brain Research·Brian E CairnsPeter Svensson
Jul 20, 2016·Pharmacology Research & Perspectives·Hiroka SuzukiKatsuhiko Muraki

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