PMID: 6978166Mar 25, 1982Paper

Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC)

Brain Research
D ChitourD Le Bars

Abstract

The involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC) acting on dorsal horn convergent neurones has been studied in the anaesthetized rat. 35 neurones activated by transcutaneous electrical stimulation of their hindpaw receptive fields giving clear large A-fibre and C-fibre responses were recorded. These activities were conditioned by DNIC, evoked by either noxious heat applied to the tail or noxious pinch of the nose. Cinanserin (4 mg/kg i.v.) and metergoline (5 mg/kg i.v.), serotonin (5-HT) receptor blockers, strongly reduced the inhibitory effects of DNIC whilst having no significant effect on the non-conditioned responses. 5-Hydroxytryptophan, a precursor of 5-HT synthesis, significantly potentiated the effect of DNIC. These results indicate an important role for descending serotonergic pathways in DNIC. The functional role of this system is discussed.

References

Feb 1, 1977·Canadian Journal of Physiology and Pharmacology·B S Sastry, J W Phillis
May 13, 1977·Brain Research·H L FieldsS D Anderson
Nov 21, 1975·Brain Research·H K Proudfit, E G Anderson
May 17, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·T Magnusson
Mar 21, 1980·European Journal of Pharmacology·W S Young, M J Kuhar
Jul 25, 1980·European Journal of Pharmacology·R B McCall, G K Aghajanian

❮ Previous
Next ❯

Citations

Jul 4, 2006·Experimental Brain Research·Miriam KunzStefan Lautenbacher
Oct 12, 2012·Current Pain and Headache Reports·Carol A CourtneyT George Hornby
Aug 15, 2013·Current Pain and Headache Reports·Yelena Granovsky
May 1, 1994·Journal of the Autonomic Nervous System·M J ChandlerR D Foreman
Dec 10, 1999·Neurophysiologie clinique = Clinical neurophysiology·J C WillerD Le Bars
Feb 15, 2000·Anaesthesia·E L OngC K Koay
Jun 7, 2013·The Clinical Journal of Pain·Nathalie A RousselRob Oostendorp
Jan 1, 1992·The European Journal of Neuroscience·J. KalliomäkiA. H. Dickenson
Jun 17, 2006·Cephalalgia : an International Journal of Headache·G SandriniG Nappi
Aug 1, 2013·Medicine and Science in Sports and Exercise·Kelly M Naugle, Joseph L Riley
Feb 4, 2014·International Journal of Clinical Rheumatology·Roland Staud
Mar 20, 2012·Digestive Diseases and Sciences·Jae Woong LeeChong Il Sohn
Jul 2, 2011·The Journal of Pain : Official Journal of the American Pain Society·Roi TreisterElon Eisenberg
May 31, 2011·Respiratory Physiology & Neurobiology·Eiko YashiroTakashi Nishino
Jan 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Gerrit van Wijk, Dieuwke S Veldhuijzen
Jan 21, 2016·Pain Research and Treatment·Andrew D Vigotsky, Ryan P Bruhns
Sep 25, 2015·The Journal of Pain : Official Journal of the American Pain Society·Bahar ShahidiKatrina S Maluf
Nov 17, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J-M SabatéB Coffin
Dec 21, 2013·Psychophysiology·Laura D EllingsonDane B Cook
Jul 1, 1992·Progress in Cardiovascular Diseases·A MaseriG Davies
Jan 1, 1986·Annals of the New York Academy of Sciences·G CurzonM D Tricklebank
Jul 4, 2006·The Journal of Pain : Official Journal of the American Pain Society·M T Carrillo-de-la-PeñaC Gómez-Perretta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.