Pharmacological features of osthole

Postȩpy higieny i medycyny doświadczalnej
Agata JarząbAndrzej Stepulak

Abstract

Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities. One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L.) Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.). It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved. The impact of osthole on bone metabolism has been demonstrated; also its hepatoprotective and neuroprotective properties have been confirmed. The inhibitory effect of this metokcompound on the development of neurodegenerative diseases has been proved in experimental models. Anticancer features of osthole have been also demonstrated both in vitro on different cell lines, and in vivo using animals xenografts. Osthole inhibited proliferation, motility and invasiveness of tumor cells, which may be associated with the induction of apoptosis and cell cycle slowdown. The exact molecular mechanism of osthole anti-cancer mode of action has not been fully elucidated. A synergistic effect of osth...Continue Reading

Citations

Jul 31, 2018·Mediators of Inflammation·Yiyi JinGuang Liang
Jan 23, 2019·The International Journal of Neuroscience·Yu WangRuiqin Yao
Apr 3, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hui HeChao Yu
May 8, 2020·Oxidative Medicine and Cellular Longevity·Emad H M HassaneinAyman M Mahmoud
Jul 30, 2019·Frontiers in Pharmacology·Weixiao AnShousong Cao
Feb 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Dianna LiuGansheng Zhong

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