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Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

Cell Chemical Biology

May 15, 2018

Elvira SondoNicoletta Pedemonte

Abstract

In cystic fibrosis (CF), deletion of phenylalanine 508 (F508del) in the CFTR channel is associated with misfolding and premature degradation of the mutant protein. Among the known proteins associated with F508del-CFTR processing, the ubiquitin ligase RNF5/RMA1 is particularly interestin...read more

Mentioned in this Paper

In Vivo
Cratoxylum formosum
Bronchial System
RNF5
RNF5 gene
Apoptosis, Intrinsic Pathway
Cftr
Structure-Activity Relationship
CFTR protein, human
Ubiquitin
1
1
24

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Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

Cell Chemical Biology

May 15, 2018

Elvira SondoNicoletta Pedemonte

PMID: 29754957

DOI: 10.1016/j.chembiol.2018.04.010

Abstract

In cystic fibrosis (CF), deletion of phenylalanine 508 (F508del) in the CFTR channel is associated with misfolding and premature degradation of the mutant protein. Among the known proteins associated with F508del-CFTR processing, the ubiquitin ligase RNF5/RMA1 is particularly interestin...read more

Mentioned in this Paper

In Vivo
Cratoxylum formosum
Bronchial System
RNF5
RNF5 gene
Apoptosis, Intrinsic Pathway
Cftr
Structure-Activity Relationship
CFTR protein, human
Ubiquitin
1
1
24

Similar Papers Found In These Feeds

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